短暂性脑缺血后脑梗死与纤维蛋白原水平的相关性研究

After transient cerebral ischemia cerebral infarction and fibrinogen levels of correlation

目的探讨短暂性脑缺血发作(TIA)后患者发生脑梗死与血浆纤维蛋白原水平的相关性。方法回顾性分析我院128例TIA患者的病历资料,比较脑梗死患者与TIA稳定患者的临床资料和血常规、血糖、血脂、肌酐和纤维蛋白原等指标,并进行多因素Logistic回归分析。结果 128例患者中,20例(15.6%)患者发生脑梗死,脑梗死患者与稳定患者的一般资料和血常规、血糖、血脂、肌酐等资料比较差异无统计学意义(P>0.05);脑干梗死患者的血浆纤维蛋白原水平显著高于稳定患者(P<0.05);多因素Logistic回归分析结果显示,纤维蛋白原与TIA患者脑梗死的发生具有显著相关性(OR=0.625,P<0.05)。结论纤维蛋白原是TIA患者发展为脑梗死的独立危险因素,其水平高低可以作为短暂性脑缺血患者预后的辅助判断指标。

Objective To investigate the transient ischemic attack（TIA） patients after cerebral infarction and plasma fibrinogen level correlation.Methods A retrospective analysis of clinical data of 128 cases of TIA,comparison of cerebral infarction patients and patients with stable clinical data and blood routine,blood glucose,blood lipid,serum creatinine and fibrinogen and other indicators,and multiple Logistic regression analysis.Results In the 128 patients,20 cases（15.6%） occurred in patients with cerebral infarction,cerebral infarction patients with stable patients general information and blood routine,blood glucose,lipid,creatinine data compare difference not to have statistical significance（P0.05）;brainstem infarction patients with plasma fibrinogen levels were significantly higher than that in patients with stable（P0.05）;Logistic regression analysis the results showed,fibrinogen and TIA in patients with cerebral infarction has significant correlation（OR=0.625,P0.05）.Conclusion Fibrinogen is TIA patients develop independent risk factor for cerebral infarction,the level can be used as a transient cerebral ischemia patients prognosis judgement index.