急性脑梗死患者甲状腺激素水平变化临床分析

The clinical analysis of serum thyroid hormones levels in patients with acute cerebral infarction

目的探讨急性脑梗死患者甲状腺激素水平变化及其临床意义。方法动态观察60例急性脑梗死患者治疗前后甲状腺激素水平,同时检测40例健康对照者甲状腺激素水平,并对2组及治疗前后进行比较。结果与对照相比,治疗前脑梗死组血清FT3降低(P<0.01),TSH、FT4与对照组相比差异无统计学意义(P>0.05)。脑梗死组治疗前后相比,治疗前血清FT3水平低(P<0.05),TSH、FT4差异无统计学意义(P>0.05)。脑梗死治疗后FT3、FT4、TSH水平与对照组相比无统计学意义(P>0.05)。结论脑梗死患者急性期FT3下降,随着病情好转逐渐恢复;治疗前后甲状腺激素水平的变化的测定,对于监测治疗和判断预后有一定临床意义。

Objective To investigate the clinical significance of alteration of serum thyroid hormone levels in patients with acute cerebral infarction（ACI）.Methods Free serum triiod-othyronine（FT3）,free thyroxine（FT4）and thyroiddstimu-lating hormone（TSH）were detected in 60 cases of ACI before and after treatment as well as 40 normal controls,and the results were compared.Results There were no significant changes in FT4 and TSH between ACI team before and after treatment and controls（P〉0.05）.FT3 levels were lower in patients before treatment than those of controls（P〈0.01） and in patients after treament（P〈0.05）.There were no significant changes in FT3 between ACI team after treatment and controls（P〉0.05）.Conclusion Decrease of serum FT3 levels are present in acute period in patients with ACI.It has clinical significance to detecting treatment and determine outcome prediction.