米非司酮联合清宫术在孕早期流产中应用效果分析

Analysis on the application effect of mifepristone combined with complete curettage of uterine cavity in abortion during the first trimester of pregnancy

目的:探讨米非司酮联合清宫术治疗孕早期流产的可靠性和安全性。方法:选取门诊诊断为妊娠要求行清宫术终止妊娠的380例孕早期患者为研究对象,随机将其分为观察组与对照组。对照组完善术前检查无异常后仅行清宫术治疗,观察组患者在对照组基础上术前口服米非司酮再行清宫术,观察两组患者在手术时间、出血情况、清宫成功率及并发症的情况。结果:观察组出血量明显少于对照组(P<0.01),清宫术时间及术后阴道流血时间也明显短于对照组(P<0.01);观察组完全流产率达98.42%,明显高于对照组的88.42%(P<0.01),人工流产综合征发生率2.63%明显低于对照组的14.74%(P<0.01)。结论:使用米非司酮联合清宫术治疗流产安全可靠,明显缩短了手术和出血时间,减少了出血量,降低了并发症的发生并且有效提高流产成功率,可以推广使用于今后的门诊治疗中。

Objective： To explore the reliability and security of mifepristone combined with complete curettage of uterine cavity for treatment of abortion during the first trimester of pregnancy. Methods： Three hundred and eighty patients who were diagnosed as pregnancy and demanded to conduct complete curettage of uterine cavity during the first trimester of pregnancy to terminate pregnancy in outpatient department of the hospital were selected as study objects, then they were randomly divided into observation group and control group. After preoperative examination was finished, if the results had no abnormality, the patients in control group were only treated with complete curettage of uterine cavity, the patients in observation group were treated with complete curettage of uterine cavity after oral administration of mifepris- tone before operation; the operation times, bleeding situations, successful rates of complete curettage of uterine cavity, and incidence rates of complications in the two groups were observed. Results： The amount of bleeding in observation group was statistically significantly less than that in control group （ P 〈 0. 01 ）, the operation time and postoperative vaginal bleeding time in observation group were statistically significantly shorter than those in control group （ P 〈 0.01 ） ; the complete abortion rate in observation group was 98. 42%, which was statistically significantly higher than that in control group （88. 42% ） （P 〈 0. 01 ）, the incidence rate of induced abortion syndrome in observation group was 2. 63%, which was statistically significantly lower than that in control group （ 14.74% ） （P 〈 0.01 ） . Conclusion： Mifepristone com- bined with complete curettage of uterine cavity is safe and reliable for treatment of abortion, which significantly shortens the operation time and bleeding time, reduces the amount of bleeding, the incidence rates of complications, and effectively improves the successful rate of abortion, the method is worthy to be popularized in outpatient treatment in the future.