隆朋+咪达唑仑+芬太尼复合持续静脉滴注对犬麻醉效果的影响

The anesthesia effect of the mixed medicine of Rompum, Midzolam and Fentanyl by continuous infusions in dogs

本试验选用隆朋、咪达唑仑、芬太尼3种药物复合,用微量注射泵进行持续静脉滴注,研究其对犬的麻醉效果。选用成年杂种犬6只,分别按照0.53mg/kg、0.2mg/kg、0.13μg/kg体重剂量一次性静脉输注待犬自然倒地,然后接微量注射泵持续静脉滴注,注射速度分别为22.2μg/kg/min、8.3μg/kg/min、5.5ng/kg/min,持续输注1h,评价机体各种反射活动及镇静、镇痛、肌松效果,监测体温、脉搏、呼吸、血氧饱和度、无创血压等指标。结果显示,3种药物复合,单次给药后迅速进入麻醉状态,持续静脉滴注麻醉过程平稳;生物反射迅速减弱且持续存在;镇静、镇痛和肌松效果良好;呼吸频率和血氧饱和度各时相无显著差异(P>0.05),心率和收缩压个别时相差异显著(P<0.05),舒张压、平均压及体温个别时相差异极显著(P<0.01),但均处于正常生理范围内。说明3种药物复合对犬进行麻醉单次输注起效迅速,持续静脉滴注麻醉过程平稳,对心血管、呼吸系统及体温影响较小,苏醒较快,未出现不良反应。

The purpose of this experiment ＂is to evaluate the anesthetic effect of the infusions of rompum,midzolam and fentanyl combination by microinjection pump at a constant rate. Six healthy mature dogs were injected with the speed of 0.53 mg/kg, 0.2 mg/kg, 0.13 μg/kg, until the dog naturally fell to the ground and then received microinjection pump, speed for 22.2 /μg/kg/min, 8.3 μg/kg/min, 5.5 ng/ kg/min, continuous infusions for 1 h. Simultaneously, effects of sedation, analgesia and muscle-relaxation body temperature, respiration and heart rate, blood oxygen saturation, noninvasive blood pressure and other indicators were monitored. The results show that anesthesia induced with the three drugs was quick and continuous infusions were smooth. Organism reflection was weakened quickly and existed continuous- ly. The sedative,analgesic and skelaxin effect were good. Compared with preanesthesia, RR and SpO2 were not significantly changed during the anesthesia period（P〉0.05）. HR and SAP were significantly lower than the base titre at individual time point（P〈0.05）. MAP,DAP and T were extremely significantly lower than the base titre at individual time point（P〈0.01）,but all the titres were in the normal physiologic range. It suggested that the single anesthesia was quick, the anesthesia with continuous infusions was smooth,cardiovascular, respiratory system and body temperature was small,and stage of palinesthesia was quick. Adverse reactions were not seen during the whole process.