急性胰腺炎发病机制的再认识

Re-understanding of Pathogenesis of Acute Pancreatitis

急性胰腺炎(AP)是临床常见急腹症,发病急、进展快、病死率高。但其发病机制尚不明确,严重制约了其早期预警及诊疗手段的革新。目前,传统的"酶异常激活"和"自身消化学说"已不能全面阐明其机制,而包括炎性介质和细胞因子的释放、细胞凋亡的发生以及胰腺微循环障碍等在内的一系列新理论逐渐得以证实和认可。该文就近年来AP发病机制的研究新进展作一综述。

Acute pancreatitis （ AP ）, which is a clinical common acute abdomen disease, has acute onset, raptd progression and high mortality. But its pathogenesis remains unclear,which seriously hampers the innovation of the early warning and treatment means. The traditional ＂ abnormal activation of enzymes＂ and ＂ self-digest doctrine＂ have been unable to fully elucidate its mechanism. A series of new theories,including the release of inflammatory mediators and cytokines,the occurrence of apoptosis and pancreatic microcirculation disorder were gradually con-firmed and recognized. Here is to make a review focused on the recent reexamination of the pathogenesis of AP.