摘要
抗磷脂抗体(aPL)是一组能与含有磷脂结构的抗原物质发生反应的自身抗体。通过促进血栓形成、损伤滋养细胞功能、影响免疫平衡等不同致病途径最终累及子宫及胎盘功能,导致多种病理妊娠(如复发性流产、子痫前期、胎儿生长受限、HELLP综合征等)的发生。aPL相关的病理妊娠,如复发性流产、早产、重度子痫前期等作为aPL综合征的临床诊断标准之一,对aPL阳性引起病理妊娠患者的治疗主要采用抑制血栓形成和抑制免疫反应的方法。
Anti-phospholipid antibody is a kind of autoantibodies which acts with antigens containing phospholipid structure. It affects the functions of uterus and placenta by promoting thrombosis, damaging the functions of trophoblast or impacting immunological balance, resulting in multiple pathological gestations such as recurrent abortion, preeclampsia, fetal growth restriction, and HELLP syndrome, etc.. Anti-phosphorlipid antibody relevant pathological gestation like recurrent spontaneous abortion, premature delivery, severe pre- eelamPsia is one of the clinical diagnostic standards of antiphospholipid antibody syndrome. Inhibiting throm- bosis and suppressing autoimmune reactions are the principal methods in the treatment of pathological gesta- tions caused by anti-phosphorlipid antibody.＇
出处
《医学综述》
2013年第11期1951-1954,共4页
Medical Recapitulate
关键词
病理妊娠
抗磷脂抗体
诊断
治疗
Pathological pregnancy
Anti-phospholipid antibody
Diagnosis
Treatment
