百草枯中毒的治疗进展

Treatment Progress in Acute Paraquat Poisoning

百草枯属剧毒除草剂,对人畜有较强的毒性。20世纪50年代末,百草枯的除草作用被发现,1962年首次在市场上销售,每年均有很多人死于百草枯中毒。百草枯对全身各个器官均有极强的毒性,病程进展快,病死率很高,临床表现各异,最终患者多因器官功能障碍综合征以及肺纤维化所致的低氧血症死亡。国内外学者至今仍未发现百草枯的特效解毒药物,该文就近年来百草枯中毒治疗的进展予以综述。

Paraquat is a highly toxic herbicile, which has strong toxiciiy to humans and animalsThe her- bicide effect of paraquat was found at the end of 1950s. Since its introduction in the market in 1962,there were many people died of paraquat poisoning every year. Paraquat has very strong toxicity on various organs of the body with different clinical manifestations, and ultimately the patients died of organ dysfunction syndrome （multiple organ dysfunction syndrome, MODS）, and hypoxemia caused by pulmonary fibrosis. The domestic and foreign scholars have not discovered the effective drugs for paraquat poisoning, and here is to make a review of the research on the treatment oro^ress of oaraQuat noisonin~ in recent vears.