^(99)mTcO_4^-甲状腺显像对不同时期亚急性甲状腺炎的诊断价值

Diagnostic value of ^(99)mTc^- pertechnetate thyroid imaging in different periods of subacute thyroiditis

目的探讨放射性核素99mTcO4-甲状腺显像对不同时期亚急性甲状腺炎(SAT)的诊断价值。方法选择SAT患者155例,按甲状腺功能分为甲状腺功能亢进(甲亢)组77例、甲状腺功能正常组78例。分别行甲状腺99mTcO4-显像和细针穿刺细胞学检查(FNAB),以FNAB结果为参照,观察99mTcO4-甲状腺显像诊断不同时期SAT的灵敏度和特异度。结果 99mTcO4-甲状腺显像诊断甲亢组的灵敏度为91.7%、特异度为60.0%,与FNAB检查比较差异有统计学意义(χ2=12.8,P<0.05);诊断甲状腺功能正常组的灵敏度为76.1%、特异度为57.1%,与FNAB检查比较差异无统计学意义(χ2=2.0,P>0.05)。结论 99mTcO4-甲状腺显像诊断甲亢期SAT敏感性和特异性均高于甲状腺功能正常期,可考虑作为首选方法。

Objective To investigate the diagnostic value of radionuclide 99TcO4- imaging in different periods of sub- acute thyroiditis （SAT）. Methods A total of 155 patients with SAT were divided into 2 groups, according to the thyroid function： 77 cases with hyperthyroidism and 78 eases with euthyroidism. 99mTcO4- thyroid imaging and fine needle aspira- tion biopsy （FNAB） were performed for all patients. Based on FNAB result reference, the diagnostic sensitivity and speci- ficity of 99STCO4- thyroid imaging in each group were observed respectively. Results The sensitivity and specificity in the hyperthyroid group were 91.7% and 60.0%, compared to the FNAB result, with statistical difference （X2 = 12.8 ,P 〈 0.05 ） ; the sensitivity and specificity in the euthyroid group were 76.1% and 57.1%, compared to the FNAB result, with no statistical difference （X： = 2.0,P 〉 0.05）. Conclusion Compared with euthyroid SAT, 99mTcO4- thyroid imaging can be used as the preferred method in the diagnosis of hyperthyroid SAT, because of the higher sensitivity and specificity.