B型利钠肽对急性胰腺炎预后预测的价值

Prognostic value of increased B type natriuretic peptide in cases with acute pancreatitis

目的探讨B型利钠肽(BNP)对急性胰腺炎(AP)预后预测的价值。方法选择AP患者55例(观察组)及门诊健康体检者47例(对照组),在接受治疗前及治疗后48h采集静脉血,分别进行血清BNP水平及超声心动图检查,并分析BNP与Ranson、Glasgow评分的关系。结果治疗后48h,观察组血清BNP水平明显低于治疗前(P<0.05),且治疗前、后均明显高于对照组(P<0.05);两组超声心动图检查相关指标比较差异无统计学意义(P>0.05)。相关分析显示,观察组血清BNP水平与Ran-son、Glasgow评分呈正相关(r分别为0.818、0.712,P<0.01)。结论在AP发病过程中,血清BNP水平明显升高,可作为预测其严重程度的生物学标志物之一。

Objective To assess the relationship between serum BNP concentrations and severity of AP.Methods A total of 55 in hospital patients with acute pancreatitis from March 2006to March 2011were analyzed as AP group,and 47health people were analyzed as control group.Serum BNP levels performed and disease severity was determined by Ranson and Glasgow scoring systems.analysis of BNP and Ranson,Glasgow score relations.Results The AP group serum BNP levels were significantly lower than before treatment（P〈0.05）,before and after treatment were significantly higher than the con group（P〈0.05）;related indicators of the two groups echocardiography not statistically significant（P〈0.05）.The correlation analysis showed that the AP group serum BNP level was Ranson,Glasgow score was positively correlated（r=0.818,0.712,P〈0.01）.Conclusion We think that the increase over the normal levels in serum BNP concentrations during the course of AP,could be a more plausible and objective biochemical assay for the prediction.