期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SGLT2抑制剂治疗2型糖尿病的研究进展 被引量：1

下载PDF
导出
摘要 随着糖尿病患病率的迅猛增加和控制达标率的不满意,糖尿病的治疗引起广泛关注。传统口服降血糖药物的作用机制多样,但目前上市的药物中没有一种药物是通过增加葡萄糖的排泄从而达到降血糖作用的。肾脏在人体代谢平衡的维持及血糖的调控中起着重要的作用。在健康成人中,每天大概有180g的葡萄糖从肾小球滤过,
作者 刘文曲 汪志红
机构地区 重庆医科大学附属第一医院内分泌科
出处 《重庆医学》 CAS CSCD 北大核心 2013年第17期2024-2027,共4页 Chongqing medicine
关键词 钠-葡萄糖协同转运蛋白 抑制剂 糖尿病 2型
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献23

  • 1Neumiller JJ,White JR,Campbell RK.Sodium-glucose co-transport inhibitors:progress and therapeutic potential intype 2 diabetes mellitus[J].Drugs,2010,70(4):377-385.
  • 2Debnam ES,Unwin RJ.Hyperglycemia and intestinal andrenal glucose transport:implications for diabetic renal in-jury[J].Kidney Int,1996,50(4):1101-1109.
  • 3Uldry M,Thorens B.The SLC2 family or facilitated hex-ose and polyol transporters[J].Pflugers Arch,2004,447(5):480-489.
  • 4Wright EM,Turk E.The sodium/glucose cotransport familySLC5[J].Pflugers Arch,2004,447(5):510-518.
  • 5Wright EM,Hirayama BA,Loo DF.Active sugar trans-port in health and disease[J].J Intern Med,2007,261(1):32-43.
  • 6Wright EM.Renal Na(+ )-glucose cotransporters[J].AmJ Physiol Renal Physiol,2001,280(1):10-18.
  • 7Kanai Y,Lee WS,You G,et al.The human kidney low af-finity Na +/glucose cotransporter SGLT2.Delineation ofthe major renal reabsorptive mechanism for I>glucose[J].J Clin Invest,1994,93(3):397-404.
  • 8van den Heuvel LP,Assink K,Willemsen M,et al.Auto-somal recessive renal glucosuria attributable to a mutationin the sodium glucose cotransporter(SGLT2 )[J].HumGenet,2002,lll(6):544-547.
  • 9Francis J,Zhang J,Farhi A,et al.A novel SGLT2 muta-tion in a patient with autosomal recessive renal glucosuria[J].Nephrol Dial Transplant,2004,19(11):2893-2895.
  • 10Dudosh J,Zhang X,Zeck RE,et al.Glycooylated dihydroehal-cones as potent and selective sodium glucose co-transport-ers 2(SGLT2 )inhibitors [ J],Bioorg Med Chem Lett,2004,14(20):5121-5125.

同被引文献13

  • 1TAHRAN,ANTHONY H B,CLIFFORD J B.SGLT inhibitors in management of diabetes[J].Lancet Diabetes Endorinol,2013,1(2):140-151.
  • 2FARHAD M,HMAZEN A,JOHN E G.SGLT2 inhibitors in the treatment of type 2 diabetes[J].Diabetse Res Clin Pr,2014,104(3):297-322.
  • 3BRIAN Z,IKE O,KENNY F,et al.Effects of LX4211,a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor,on postprandial glucose,insulin,glucagon-like peptide 1,and peptide tyrosine tyrosine in a dose-timing study in healthy subjects[J].Clin Ther,2013,35(8):1162-1173.
  • 4GOODWIN N C,HARRISON B A,ⅡMURA S,et al.M ethods and compounds useful for the preparation of sodium glucose co-transporter 2 inibitors:WO,2009014970[P].2009-01-29.
  • 5LIDIA D L,GIAMPAOLO G,SIMONETTA M,et al.Trichloroisocyanuric/TEM PO oxidation of alcohols under mild conditions:a close investigation[J].J Org Chem,2003,68(12):4999-5001.
  • 6FARID M I,KONSTANTIN A S,JANNE V J,et al.Reaction of 1,2-trans-glycosyl acetates w ith thiourea:a new entry to 1-thiosugars[J].Tetrahedron Lett,2003,44(43):7961-7964.
  • 7TADASHI H,HIROKI B,HIROKI T,et al.Synthetic studies on pterin glycosides:the first synthesis of 2'-O-(α-D-glucopyranosyl)biopterin[J].Tetrahedron,2009,65(38):7989-7997.
  • 8尼克勒·C·古德温,布赖斯·A·哈里森,斯彭尼尔·D·金博尔,等.钠-葡萄糖协同转运蛋白2的抑制剂及其用法:中国,101343296B[P].2013-04-10.
  • 9OSAMU M,KAZUYA Y,HIDEO T,et al.Synthesis and biological evaluation of deoxy salacinols,the role of polar substituents in the side chain on theα-glucosidase inhibitory activity[J].Bioorg M ed Chem,2006,14(2):500-509.
  • 10CHRISTIAN A,MONTALBETTI C A G N,FALQUE V.Amide bond formation and peptide coupling[J].Tetrahedron,2005,61(46):10827-10852.

引证文献1

二级引证文献1

重庆医学
2013年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部