尤卓尔联合三重修护特润霜治疗婴幼儿湿疹的疗效

Efficacy of hydrocortisone butyrate cream combined with trixera emollient cream on infantile eczema

目的观察尤卓尔联合雅漾三重修护特润霜治疗婴幼儿湿疹的疗效。方法采用随机对照开放试验,将患儿分为联合治疗组、尤卓尔组及特润霜组。联合治疗组应用尤卓尔和雅漾三重修护特润霜分别涂抹于患处,2次/d,并且根据患儿皮疹状况逐渐减少尤卓尔用量及次数,痊愈后改为单独外用雅漾三重修护特润霜维持治疗。尤卓尔组单独外用尤卓尔,2次/d,同样根据患儿皮疹情况逐渐减量。特润霜组单独外用雅漾三重修护特润霜,2次/d。于用药7、14 d及痊愈后1周复诊记录皮疹状况,观察有无不良反应。结果 7 d后,联合治疗组有效率和痊愈率分别为66.18%和45.59%,高于特润霜组(P<0.05);14 d后,联合治疗组有效率和痊愈率分别为88.24%和67.65%,高于尤卓尔组及特润霜组(P<0.05)。结论尤卓尔联合雅漾三重修护特润霜治疗婴幼儿湿疹效果良好。

Objective To observe the efficacy of hydrocortisone butyrate cream combined with eau-thermale- avene trixera emollient cream on infantile eczema. Methods A randomized controlled open trial was performed. The combined group （group A） was treated with hydrocortisone butyrate cream and eau-thermale-avene trixera emollient cream twice dally alternatively, hydrocortisone butyrate cream was gradually reduced according to the skin rash, and the emollient cream was maintained after the rash cured. The hydrocortisone butyrate cream group （ group B ） was treated with hydrocortisone butyrate cream twice daily only and the dosage was reduced gradually similarly. The emollient cream group （group C）was applied with ean-thermale-avene trixera emollient cream twice daily only. The variations of the rash were recorded and the total scores of erythema, papule, scale, pruritusand area were evaluated in the return visit of 7 and 14 d after medication and 7 d after recovery. Results The effective rate and curative rate of group A were significantly higher than those of group C after 7 d of therapy（ P 〈0. 05）. The effective rate and curative rate of group A after 14 d of therapy were all higher than those of group B and group C （ P 〈 0.05 ）. Conclusion The combination use of hydrocortisone butyrate cream and eau-thermale-avene trixera emollient cream is effective on infantile eczema.