听性脑干反应在高危儿中枢性协调障碍早期诊断中的意义

Significance of auditory brainstem response in the early diagnosis of high-risk children with zentrale koordination-storung

目的探讨高危儿听性脑干反应（ABR）的变化及其与高危儿中枢性协调障碍（ZKS）的关系。方法对2485例ZKS高危新生儿随访至1岁，其中1246例应用ECLTPSE听性脑干反应仪进行ABR检查，根据ABR检查情况分为ABR异常组、ABR正常组及ABR未查组，分析3组ZKS发生率；将行ABR检查的1246例高危儿分为ZKS组和非ZKS组，对2组患儿ABR各波潜伏期及峰问期进行比较。结果ABR异常组ZKS发生率明显高于ABR正常组（P〈0．01）。ZKS组ABR与非ZKS组比较，Ⅲ、V波潜伏期延长，Ⅲ-V及I—V波峰间期延长，差异均有统计学意义（P均〈0．05）。结论ABR在高危新生儿随访及协助诊断ZKS中具有重要临床应用价值。

Objective To investigate the change of auditory brainstem response （ABR） in high-risk children and the relationship between ABR and zentrale koordination-storung （ZKS）. Methods Two thousands four hundred and eighty-five high-risk infants were followed up to 1 year old, of which 1246 cases were measured with the ECLTPSE auditory brainstem response analyzer, the relationship of ABR and ZKS were analyzed. Results ZKS incidence of ABR abnormal group was significantly higher than that of the ABR normal group （ P 〈 0.01 ）. The ABR waveform of ZKS group compared with those of non-ZKS group ： Ⅲ, Ⅴ wave latency were longer, Ⅲ -Ⅴ and Ⅰ - Ⅴ peak interval were longer,the differences were significant （ all P 〈 0.05 ）. Conclusions ABR has important clinical value in high-risk neonatal follow-up and assisting diagnosis ZKS, and auditory pathway damage of ZKS is more common in the parts of a- bove the brainstem superior olivary nuclear.