血清白细胞介素-6水平与狼疮性肾炎活动性病变的关系

Association of serum interleukin-6 level with active lupus nephritis

目的探讨血清白细胞介素-6（interleukin-6，IL-6）的水平变化与狼疮性肾炎（1upusnephritis，LNl活动的关系。方法选择我院肾内科住院部2010年3月至2012年8月收治的LN患者84例，按照SLEDAI标准评估其疾病的活动性，评分在10分以上为活动期，评分在10分以下为稳定期。另选择与患者年龄、性别构成相匹配的40例健康人员作为健康对照组。LN活动期组患者均用环磷酰胺（CTX）加皮质激素疗法，LN稳定期组不作免疫抑制治疗，健康对照组未予以处理。采用ELISA双夹心法检测IL-6含量，比较分析三组IL-6含量变化。结果治疗前，活动期LN患者血清IL-6水平f（285．44±76．56）ng／L]显著高于稳定期患者[（63．23±44．98）ng／L]和健康人员[（50．86±40．66）ng／L]（P〈0．01）；治疗后，活动期LN患者血清IL-6水平[（86．53±68．32）ng／L]显著低于治疗前俨〈0．01）。LN稳定期组患者血清IL-6水平与健康对照组比较，差异无统训计学意义（P〉0．05）。结论血清IL-6的水平可作为LN活动度的敏感指标之一，血清IL-6的检测有助于监测狼疮活动和免疫抑制剂的疗效。

Objective To investigate the association of serum interleukin-6 （IL-6） level with active lupus nephritis （LN）. Methods 84 patients with LN who had been treated in our hospital during the period of March 2010 to August 2012 were selected. The disease activity was assessed according to the SLEDAI standards. The patients with a score of more than 10 were in the active phase and those with a score of less than 10 were in the stable phase. 40 age and sex matched healthy individuals were recruited as control subjects. The patients in the active phase received cyclophosphamide （CTX） and cortical hormone, while those in the stable phase received no immunosuppressive therapy, and the healthy control subjects did not receive any treatment. IL-6 contents were detected by double sandwich ELISA. The changes in IL-6 contents were compared and analyzed among the three groups. Results Before treatment, Serum IL-6 level was significantly higher in patients in the active phase than those in the stable phase and the healthy controls [（285.44 ± 76.56） ng/L vs. （63.23 ± 44.98） ng/L vs. （50.86 ± 40.66） ng/L, P〈O.01]. After treatment, serum IL-6 level [（86.53 ± 68.32） ng/L] was significantly declined as compared with the baselines （P〈O.01）. The serum IL-6 level did not differ statistically between the patients in the stable and the healthy control subjects （/9〉0.05）. Conclusions Serum IL-6 level can be used as a sensative marker for the disease activity of lupus nephritis. Detection of serum IL-6 is beneficial and useful for monitoring disease activity and effects of immunosuppressive drugs.