妊娠合并甲状腺功能减退症对子代的影响

Pregnancy with hypothyroidism and infants

妊娠早期孕妇患甲状腺功能减退症会影响胎儿脑神经功能的发育,出生后的婴儿智力受损,神经发育迟缓,语言、精细活动能力受损,学习障碍的概率增加,视觉空间思维能力下降;经治疗甲状腺功能恢复正常的孕妇,胎儿脑功能可发育正常。妊娠合并亚临床甲状腺功能减退症对子代发育的影响文献报道不一,孕期治疗亚临床甲状腺功能减退症的益处未得到证实。

Maternal hypothyroidism during early pregnancy is associated with impaired fetal brain development. Infants of women with hypothyroxinemia before 12 weeks＇ gestation have significantly lower IQ scores, decreased neurological development, compromised language and motor ability compared with normal subjects. If maternal hypothyroxinemia have been redressed, the infants would have normal neurodevelopment. It is not clear whether thyroid hormone replacement for women with subclinical hypothyroidism would improve the infants wellbeing.