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ARK5与肿瘤侵袭转移相关性的研究进展 被引量：1

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摘要 ARK5(AMPK-related protein kinase 5,又称NUAK1)是AMPK(AMP-activated protein kinase)的亚家族成员之一,其是Akt的下游信号分子。ARK5在各种肿瘤细胞系中表达,有研究表明ARK5能促进肿瘤的发生和抑制肿瘤细胞的凋亡,且Akt-ARK5通路与肿瘤的恶性发展密切相关。该文对ARK5在肿瘤侵袭和转移中的作用,及其与肿瘤侵袭相关的信号分子的相互关系进行综述。
作者 史圆圆 路名芝
机构地区 南昌大学医学院 江西省人民医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第6期665-668,共4页 Chinese Journal of Clinical and Experimental Pathology
基金 江西省卫生厅科技计划(20113015)
关键词 肿瘤 侵袭 转移 ARK5
分类号 R73-37 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1Suzuki A, Kusakai GI, Kishimoto A, et al. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein[J]. J Biol Chem, 2003,278(1):48-53.
  • 2Suzuki A, Esumi H. AMPK in the cancer research field: tumor progression by ARK5[J]. Seikagaku, 2006,78 (5):392403.
  • 3Hennessy B T, Smith D L, Ram P T, et al. Exploiting the PI3K/AKT pathway for cancer drug discovery[J]. Nat Rev Drug Discov, 2005,4(12):988-1004.
  • 4Kusakai G, Suzuki A, Ogura T, et al. ARK5 expression in colorectal cancer and its implications for tumor progression[J]. Am J Pathol, 2004,164(3):987-95.
  • 5Kusakai G, Suzuki A, Ogura T, et al. Strong association of ARK5 with tumor invasion and metastasis[J]. J Exp Clin Cancer Res, 2004,23(2):263-8.
  • 6Kusakai G, Suzuki A, Ogura T, et al. Strong association of ARK5 with tumor invasion and metastasis[J]. J Exp Clin Cancer Res, 2004,23(2):263-8.
  • 7McSherry E A, Donatello S, Hopkins A M, et al. Molecular basis of invasion in breast cancer[J]. Cell Mol Life Sci, 2007,64(24):3201-18.
  • 8Suzuki A, Lu J, Kusakai G, et al. ARK5 is a tumor invasionassociated factor downstream of Akt signaling [J]. Mol Cell Biol, 2004,24(8):3526-35.
  • 9姬静,张宝刚,张伟栋,郭爱华,崔若凡,杨兴杰.ARK5与乳腺癌侵袭转移关系的研究[J].临床与实验病理学杂志,2012,28(4):382-385. 被引量：15
  • 10Chen P, Li K, Liang Y, et al. High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion[J]. Exp Lung Res, 2013,39(1):9-17.

二级参考文献13

  • 1Suzuki A,Kusakai G,Kishimoto A,et al.Identification of a no-vel protein kinase mediating Akt survival signaling to the ATM pro-tein[J].J Biol Chem,2003,278(1):348-53.
  • 2Suzuki A,Kusakai G,Kishimoto A,et al.ARK5 suppresses thecell death induced by nutrient starvation and death receptors viainhibition of caspase 8 activation,but not by chemotherapeutic a-gents or UV irradiation[J].Oncogene,2003,22(40):6177-82.
  • 3Suzuki A,Ogura T,Esumi H.NDR2 acts as the upstream kinaseof ARK5 during insulin-like growth factor-1 signaling[J].J BiolChem,2006,281(20):13915-21.
  • 4Suzuki A,Lu J,Kusakai G,et al.ARK5 is a tumor invasion-as-sociated factor downstream of Akt signaling[J].Mol Cell Biol,2004,24(8):3526-35.
  • 5Kusakai G,Suzuki A,Ogura T,et al.ARK5 Expression in Color-ectal Cancer and Its Implications for Tumor Progression[J].Am JPathol,2004,164(3):987-95.
  • 6Zhang B,Gu F,She C,et al.Reduction of Akt2 inhibits migra-tion and invasion of glioma cells[J].Int J Cancer,2009,125(3):585-955.
  • 7Bieche I,Tozlu S,Girault I,et al.Identification of a three-geneexpression signature of poor-prognosis brest carcinoma[J].MolCancer,2004,3(1):37.
  • 8Van Trappen P O,Ryan A,Carroll M,et al.A model for co-ex-pression pattern analysis of genes implicated in angiogenesis andtumour cell invasion in cervical cancer[J].Br J Cancer,2002,87(5):537-44.
  • 9Suzuki A,Iida S,Kato-Uranishi M,et al.ARK5 is transcription-ally regulated by the Large-MAF family and mediates IGF-1-in-duced cell invasion in multiple myeloma:ARK5 as a new moleculardeterminant of malignant multiple myeloma[J].Oncogene,2005,24(46):6936-44.
  • 10McSherry E A,Donatllo S,Hopkins A M,McDonnell S.Molecu-lar basis of invasion in breast cancer[J].Cell Mol Life Sci,20O7,64(24):3201-18.

共引文献14

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临床与实验病理学杂志
2013年 第6期

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