甘精胰岛素联合阿卡波糖在老年糖尿病患者中的应用

Therapeutic effect of glargine insulin combined with acarbose in elderly diabetic patients

目的探讨甘精胰岛素联合阿卡波糖治疗老年糖尿病的临床疗效及安全性。方法将96例老年糖尿病患者分为观察组52例和对照组44例，观察组给予甘精胰岛素联合阿卡波糖治疗，对照组给予精蛋白锌重组赖脯胰岛素治疗，观察两组患者治疗效果。结果两组患者治疗后FEG、2PBG及HbA1c均明显低于治疗前（P〈0．05）；两组患者治疗后各血糖指标比较差异无统计学意义（P〉0．05）。观察组低血糖发生率为3．64％，明显低于对照组的15．91％（P〈0．05）。结论甘精胰岛素联合阿卡波糖治疗老年糖尿病安全、有效，更易被患者接受。

Objective To investigate the clinical efficacy and safety of glargine insulin combined with protamine zinc recombinant lispro insulin in elderly diabetic patients. Methods 96 cases of elderly diabetic were divided into the observation group （52 cases） and control group （44 cases）, the control group was given protamine zinc recombinant insulin lispro treatment, and therapeutic effect was observed. Results After treatment FEG, 2PBG and HbA l c were significantly lower than those before treatment （P〈0.05）; after treatment, glycemic index showed no significant difference between the two groups （P〉0.05）; the observation group＇ s hypoglycemia was 3.64%, significantly lower than 15.91% of the control group （P〈0.05）. Conclusion The combined therapy of the glargine insulin and acarbose treatment for senile diabetes is secure, effective, and patients are easier to accept.