瓜蒌皮注射液对动脉硬化闭塞症术后疗效观察

Efficacy of pericarpium trichosanthis injection in patients with arteriosclerosis obliterans after surgery

目的观察瓜蒌皮注射液对下肢动脉硬化闭塞症患者（ASO）球囊扩张＋支架植入术后的疗效观察。方法选取我院2006年至2010年行球囊扩张＋支架植入手术的ASO患者39例，随机分为治疗组20例（22条患肢）和对照组19例（20条患肢）。所有患者术后均予以抗凝扩管治疗，治疗组予以瓜萎皮注射液8ml加入生理盐水250ml中静滴，疗程为15d。观察术后3个月和6个月时患肢的临床症状、血管通畅率及踝肱指数。结果术后3个月和6个月时两组痛感、冷感、皮色、皮温、间歇性跛行、静息痛、溃疡、血管通畅、踝肱指数和截肢等方面比较差异有统计学意义（P〈0．05）。结论瓜萎皮注射液对ASO患者球囊扩张＋支架植入术后的临床症状及血管通畅情况的改善均起到一定作用。

Objective To observe the efficacy of pericarpium trichosanthis injection in patients with lower limb arteriosclerosis obliterans （ASO） after balloon dilatation and stent implantation. Methods From 2006 to 2010 in our hospital, 39 patients with ASO after balloon dilatation and stent implantation were randomly divided into the treatment group （20 patients with 22 limbs in ill） and the control group （19 patients with 20 limbs in i11） . All the patients were treated with anticoagulant and flaring therapy. In addition, patients in the treatment group were injected with 8 ml pericarpium trichosanthis injection in 250 ml 0.9% saline for 15 days. Clinical syndrome, vascular patency rate and ankle brachial index were observed for 3 and 6 months after surgery. Results 3 and 6 months after surgery, there were significant differences in pain, apathetic, skin color, skin temperature, intermittent claudication, rest pain, ulcer, rate of vascular patency and ankle brachial index between two groups （P〈0.05）. Conclusion Pericarpinm trichosanthis injection can improve the clinical syndrome and vascular patency rate in patients with ASO after surgery.