胺碘酮在充血性心力衰竭并室性心律失常治疗中的效果分析

Clinical Effectacy Analysis of Amiodarone on Congestive Heart Failure with Ventricular Arrhythmia

目的:探讨胺碘酮治疗充血性心力衰竭并室性心律失常的临床效果及使用安全性。方法:选择我院2010年1月-2012年12月期间住院的76例充血性心力衰竭并室性心律失常的患者,分为治疗组(在常规抗心力衰竭治疗的基础上加胺碘酮治疗)和对照组(常规抗心力衰竭治疗),观察治疗后两组患者的抗心律失常及心功能改善比率,比较心率、血压、左室射血分数(LVEF)、QT间期及药物不良反应。结果:治疗组抗室性心律失常、心功能改善效果及LVEF明显高于对照组,差异有统计学意义(P<0.05),治疗组心率、QT间期较对照组明显改善,差异有统计学意义(P<0.05),两组的不良反应差异无统计学意义(P>0.05)。结论:胺碘酮对充血性心力衰竭合并室性心律失常的治疗有效安全。

To explore the clinical effect and the use of security of amiodarone on congestive heart failure and ventricular arrhythmia. Methods： 76 patients with congestive heart failure with ventricular arrhythraias hospitalized in our hospital during January 2010 to December 2012 were divided into treatment group （plus amiodarone therapy on the basis of the conventional anti-heart failure therapy） and control group （conventional anti-heart failure treatment）. Antiarrhythmic and improving Cardiac function in patients were observed after treatment in two groups, comparing heart rate, blood pressure, left ventricular ejection fraction （LVEF）, the QT interval and adverse drug reactions. Results： Effectiveness of anti ventricular arrhythmias and improving cardiac function and LVEF in treatment group was significantly higher than in control group, the difference was statistically significant （P〉0. 05）. Heart rate, QT interval of the treatment group improved significantly compared with the control group, the difference was statistically significant too （P〉0. 05）. Adverse reactions of the two groups showed no significant difference（P〉0. 05）. Conclusion： Amiodarone in the treatment of congestive heart failure with ventricular arrhythmias is effective and safe.