肝卵圆细胞的研究进展
摘要
肝脏是成人体内为数不多的有再生功能的器官,部分肝切除后的肝再生期间,肝实质细胞的修复主要依靠剩余的肝实质细胞的增殖。肝脏在短时期内即可完成再生。而在肝脏受到严重损伤、不能完成再生修复功能时,肝干细胞即开始发挥重要作用,完成增殖分化从而修复肝脏功能。而肝卵圆细胞,作为肝干细胞的一种,近年来吸引了大量学者的关注。
出处
《中国实用医刊》
2013年第12期124-126,共3页
Chinese Journal of Practical Medicine
参考文献24
-
1Zvibel Isabel,Bronstein Miri,Hubel Einav,Bar-Lev Ella,Halpern Zamir,Oren Ran.Isolation, characterization and culture of Thy1-positive cells from fetal rat livers[J].World Journal of Gastroenterology,2006,12(24):3841-3847. 被引量:7
-
2Oh SH, Hatch HM, Petersen BE. Hepatic oval ' stem' cell in liver re- generation [ J ]. Semin cell Dev Biol, 2002,13 ( 6 ) :405 -409.
-
3Menthena A, Deb N, Oertel M, et al. Bone marrow progenitors are not the source of expanding oval ceils in injured liver [ J ]. Stem Cells, 2004, 22(6) :1049-1061.
-
4Bird TG, Lorenzini S, Forbes SJ. Activation of stem cells in hepatic diseases[ J]. Cell Tissue Res,2008,331 ( 1 ) :283-300.
-
5Jelnes P, Smltoni-Rugiu E, Rasmussen M, et al. Remarkable heteroge- neity displayed by oval cells in rat and mouse models of stem cell-me- diated liver regeneration [J]. Henatolozv.2007.45 ( 6 ) : 1462-1470.
-
6余幼林,施宝民.肝卵圆细胞分子标志物的研究进展[J].世界华人消化杂志,2011,19(35):3610-3615. 被引量:3
-
7Yovchev MI, Grozdanov PN, Zhou H, et al. Identification of adult he-patio progenitor cells capable of repopulating injured rat liver [ J ]. Hepatology, 2008,47 ( 2 ) : 636 -647.
-
8Liu WH, Li R, Dou KF. Convenient and efficient enriehrnent of the CD133 + hver cells from rat fetal liver cells as a source of liver stern/ progenitor cells[ J]. Stem Cell Rev ,2011,7 ( 1 ) : 94-102.
-
9Erker L, Grompe M. Signaling networks in hepatic oval cell activa- tion[ J]. Stem Call Res,2007,1 (2) :90-102.
-
10黄汉华,陈孝平,张伟,等.肝卵圆细胞分化调控机制的研究进展[J].中图现代普通外科进展,2007,10(3):236-239.
二级参考文献56
-
1Parveen Nyamath,Ayesha Alvi,Aejaz Habeeb,Sanjeev Khosla,Aleem A Khan,CM Habibullah.Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker[J].World Journal of Gastroenterology,2007,13(16):2319-2323. 被引量:9
-
2Braun KM,Thompson AW,Sandgren EP.Hepatic microenvironment affects oval cell localization in albuminurokinase-type plasminogen activator transgenic mice.Am J Pathol 2003; 162:195-202
-
3Forbes S,Vig P,Poulsom R,Thomas H,Alison M.Hepatic stem cells.J Pathol 2002; 197:510-518
-
4Stieger B,Peters R,Sidler MA,Meier PJ.Hepatocyte transplantation:potential of hepatocyte progenitor cells and bone marrow derived stem cells.Swiss Med Wkly 2006; 136:552-556
-
5Menthena A,Deb N,Oertel M,Grozdanov PN,Sandhu J,Shah S,Guha C,Shafritz DA,Dabeva MD.Bone marrow progenitors are not the source of expanding oval cells in injured liver.Stem Cells 2004; 22:1049-1061
-
6Howard BJ,Pohorecki R,Becker GL,Landers DF.Energy status in anoxic rat hepatocytes:effects of isoflurane,solution composition,and hypothermia.Liver Transpl Surg 1995; 1:220-224
-
7Ber ry MN,Hal l s HJ,Gr ivel l MB.Techniques for pharmacological and toxicological studies with isolated hepatocyte suspensions.Life Sci 1992; 51:1-16
-
8Seglen PO.Preparation of isolated rat liver cells.Methods Cell Biol 1976; 13:29-83
-
9Tirnitz-Parker JE,Tonkin JN,Knight B,Olynyk JK,Yeoh GC.Isolation,culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient,ethioninesupplemented diet.Int J Biochem Cell Biol 2007; 39:2226-2239
-
10Fausto N,Campbell JS.The role of hepatocytes and oval cells in liver regeneration and repopulation.Mech Dev 2003; 120:117-130
共引文献28
-
1夏强.肝移植[J].中国继续医学教育,2011,3(6):35-40. 被引量:1
-
2Xian-Jie Shi,Hong-Bin Xu,Wen-Bin Ji,Yu-Rong Liang,Wei-Dong Duan,Lei He,Ming-Jun Wang and Zhi-Ming Zhao Department of Hepatobiliary Surgery Department of Anesthesiology General Hospital of PLA,Beijing 100853,China.Efficacy of liver transplantation for acute hepatic failure:asingle-center experience[J].Hepatobiliary & Pancreatic Diseases International,2011,10(4):369-373. 被引量:2
-
3黄晓明,焦兴元,胡以则.肝卵圆细胞来源分化增殖的研究进展[J].国际外科学杂志,2007,34(8):553-555. 被引量:3
-
4陈川,王阁,索金友,郑继军,张志敏,李琼,许文,雒喜中,邓婧,王红中,李增鹏,王东.原发性肝癌不同病理组织类型中肝干细胞的分析(英文)[J].中国组织工程研究与临床康复,2008,12(3):573-577. 被引量:1
-
5曾三平,焦兴元,胡以则.SDF-1/CXCR4轴与肝干细胞的研究进展[J].中华肝胆外科杂志,2008,14(10):747-749. 被引量:2
-
6叶婷婷,陆颖理.肝脏卵圆细胞向胰岛β细胞分化的研究现状[J].组织工程与重建外科杂志,2008,4(5):295-297. 被引量:1
-
7叶婷婷,陆颖理.肝脏卵圆细胞分选与向胰岛β细胞分化研究现状[J].国际内科学杂志,2008,35(10):593-596.
-
8赵丽娟,余娇,李影,陈奕,夏芳珍,王宁荐,陆颖理.不同品系大鼠肝脏卵圆细胞增殖模型的比较研究[J].上海交通大学学报(医学版),2010,30(4):381-385. 被引量:5
-
9陈胜平,吴浩荣,吴锦昌.绿色荧光蛋白标记的肝细胞移植治疗放射性肝损伤[J].南京医科大学学报(自然科学版),2010,30(8):1100-1104. 被引量:2
-
10郭红英,朱慧,张正国,屈莉红,肖宏,冯艳玲,向明,李方明,胡祥,王介非.人脐带间充质干细胞治疗急性肝功能衰竭大鼠的疗效[J].中华传染病杂志,2011,39(5):261-266. 被引量:2
-
1黄黎莹,沈培晓,汪海娅.循环CD34^+细胞数量与老年高血压的关系[J].上海交通大学学报(医学版),2016,36(3):403-406. 被引量:1
-
2郭郁文,郭力.肝切除后能再生[J].大众健康,2006(3):13-13.
-
3王恕同,李薇,黄力,胡文杰,梁力建,赖佳明.ω-3鱼油脂肪乳对肝硬化肝切除大鼠术后影响的研究[J].中华肝胆外科杂志,2012,18(10):792-794.
-
4杨晓静,姜翠英,王谦.特发性血小板减少性紫癜患者血小板再生功能的测定及临床意义[J].临床检验杂志,2004,22(6):456-456.
-
5王志强,王大志,姜红滨.血管紧张素转换酶抑制剂在心肌梗死中的应用研究[J].首都医药,2004,11(12):31-33.
-
6汤红,许德清.系统性红斑狼疮患者及其家族成员DNA修复功能的探讨[J].中华皮肤科杂志,1994,27(6):362-363.
-
7黄亚莉,汪燕,陆彤.内皮前体细胞功能与临床应用[J].第二军医大学学报,2010,31(5):545-548. 被引量:1
-
8胡宗义,武忠弼.雌激素对大鼠部分肝切除后再生过程中肝血管内皮细胞增生的影响[J].同济医科大学学报,1992,21(4):221-223. 被引量:1
-
9周俊英,甄真,张淑环,刘金星.病毒性肝炎患者血清胆碱酯酶、凝血酶原活动度检测的临床意义[J].临床荟萃,2004,19(18):1024-1025. 被引量:1
-
10一种特殊蛋白能修复瘢痕[J].中国乡村医药,2007,14(9):83-83.