面向乳腺诊断的血氧扩散光学层析方法:仿体实验与在体评估

Hemoglobin Diffuse Optical Tomography for Breast Tumor Diagnosis: Phantom Experiment and in Vivo Evaluation

为了获得乳腺诊断的功能影像信息,设计了一套面向乳腺肿瘤早期诊断的血氧扩散光学层析(DOT)成像系统。该时域测量系统采用时间相关单光子计数技术,获得溢出目标体表面的光子随时间变化的分布信息,为了兼顾测量时间和系统成本,采用了四通道并行测量模块与光开关相结合的架构,能够降低不同通道之间的性能差异,减少伪像对诊断的干扰。采用基于广义脉冲谱技术的特征数据算法实现了光学参数(吸收系数、约化散射系数)的同时重建。通过仿体实验和初步临床研究对所提出的时域血氧DOT方法进行了验证,结果表明,该方法可以有效重建乳腺组织中光学参数的空间分布,进而获得乳腺组织功能信息,用于乳腺肿瘤的早期检测。

A time-resolved hemoglobin-diffuse optical tomography （DOT） system is proposed for the early breast tumor optical measurements, which is developed to produce functional images of the female breast. The system applies time-correlated single photon counting method to acquire the time-resolved light distributions of the light re-emissions from the boundaries. To keep the balance between detection time and hardware cost, a combined framework made up of four-channel parallel-detecting module and optical switches is used, which could decrease the influence of channels′ attenuation differences and reduce the interference arising from the artifacts. The simultaneous reconstructions of the two optical （absorption and scattering） properties are achieved with the respective featured-data algorithms based on the generalized pulse spectrum technique. The performances of the methodology are assessed on breast-mimicking phantom and pilot experiments. The results demonstrate the efficacy of the hemoglobin-DOT for breast tumor diagnosis that the optical parameters can be reconstructed simultaneously, and the corresponding function information is useful for early breast tumor diagnosis.