摘要
目的:评价miR-21的高表达与结直肠癌预后的相关性。方法:通过全面检索PubMed、EMBASE、Google scholar、维普、CNKI等数据库,收集关于miR-21的高表达与结直肠癌预后相关性的文献,用meta分析方法评价miR-21的高表达是否与结直肠癌的预后相关。结果:共纳入4篇文献(共783个病例),总生存率(OS)HR的合并值为1.42,95%CI:1.21至1.66,P<0.05。结论:miR-21的高表达是结直肠癌预后的一个危险因素。
Objective：To evaluate the correlation between the high expression of miR - 21 and the prognosis of colorectal cancer. Methods： Eligible studies which studied the correlation between the high expression of miR - 21 and the prognosis of colorectal cancer were collected through searching PttbMed, EMBASE, and Google scholar, VIP, CNKI databases. A meta analysis method was used to evaluate whether the high expression of miR - 21 has an association with the prognosis of cohirectal cancer. Results： A total of 4 studies were involved in this meta - analysis. For overall survival （ OS ）, the pooled hazard ratio （ HR ） of higher miR - 21 expression in cancerous tissues was 1.42 95 % CI： 1.21 - 1.66, P 〈 0.05 Conchisions： The association of high expression of miR - 21and the prognosis of colorectal cancer is negative.
出处
《激光杂志》
CAS
CSCD
北大核心
2013年第3期77-78,共2页
Laser Journal
