微波辐射下干介质中酰氨基硫脲及其关环产物合成的研究

Study on Synthesis of Acyl Thiosemicarbazide and Its Ring Closure Products in Dry Media under Microwave Irradiation

本文用苯乙酰肼与苯基异硫氰酸酯在微波辐射下以氧化铝为介质进行反应 ,合成 1 苯乙酰基 4 苯 基氨基硫脲 ;然后分别将其在冰醋酸、醋酸汞存在下关环 ,制得 2 苯甲基 5 苯胺基 1,3 ,4 噻二唑与 2 苯甲基 5 苯胺基 1,3 ,4

This paper reports the synthesis of 1 phenylacetyl 4 phenyl thiosemicarbazide from phenylacetyl hydrazine and phenyl isothiocyanate with aluminium oxide as a surpport under microwave irradiation.This thiosemicarbazide was treated under the catalysis of glacier acetic acid,mercuric acetate giving 2 benzyl 5 phenylamino 1,3,4 thiodiazole and 2 benzyl 5 phenylamino 1,3,4 oxadiazole respectively.