分辨学习中海马CA_1区不同传入通路的突触传递效能变化

CHANGES OF SYNAPTIC TRANSMISSION EFFICACY AT DIFFERENT TO CA_1 AREA OF HIPPOCAMPUS DURING DISCRIMINATION LEARNING

采用电生理学与行为学的结合方法，通过慢性埋植微电极技术，观察到大鼠在明暗分辨学习的建立过程中，海马 ＣＡ_１区不同传入突触上（Ｓｃｈａｆｆｅｒ－ＣＡ_１与 Ｐｅｒｆｏｒａｎｔ Ｐａｔｈ－ ＣＡ_１）均同步产生传递效能的长时程增强（ＬＴＰ）变化，在产生这一习得性ＬＴＰ的幅度上，ＰＰ－ＣＡ_１大于Ｓｃｈ－ＣＡ_１．而对照的假性训练动物却均未见到有这种变化，差异显著（Ｐ＜０．００１）．结果表明ＣＡ区的不同传入通路在参与学习中均协同地产生突触效能变化，这为从神经回路角度探讨学习与记忆的神经机制提供有意义的证据，作者并就此予以讨论．

Electrophysiological and behavioral studies were conducted to investigate the changes of synaptic effcacy of the two inputs into CA_1 area (Schaffer - CA_1 and Perforant path - CA_1 ) during discrimination learning in rats. The results showed that the learning - dependent long - term potentiation (LTP) in both inputs developed synchronously following learning, while pseudotraining rats did not show such changes. These results suggest that the changes of synaptic efficacy of different inputs of hippocampus CA_1 area coordinated during discrimination learning.