三唑磷对大鼠神经行为的影响

Effect of triazophos on the neurobehavior in rats

[目的]研究三唑磷对大鼠神经行为的影响作用。[方法]40只体重60～80 g的SD大鼠,雌雄各半,随机分成4组,将受试物掺入饲料中给予染毒,共设对照、低、中、高4组,剂量分别为0、25、100、400 mg/kg。给予受试物16周后进行Morris水迷宫试验测试神经行为功能。[结果]在定向导航试验中,在不同训练期中、高剂量组雄性大鼠的潜伏期有不同程度的延长,且与对照组相比差异有统计学意义(P<0.05),雌性大鼠各训练期的逃避潜伏期与对照组相比差异无统计学意义;在空间探索试验中,低、中、高剂量组雌性大鼠的平均运动速度与对照组大鼠相比差异均有统计学意义(P<0.05);中、高剂量组雌性大鼠在目标象限的活动时间与对照组相比有显著减少(P<0.05);雄性大鼠高剂量组站台周围活动时间与对照组有显著减少(P<0.05),雌性大鼠的中、高剂量组站台周围活动时间与对照组相比有显著减少(P<0.05)。[结论]三唑磷可对大鼠的神经行为产生一定的影响。

[ Objective ] To evaluate the effect of Triazophos on the neurobehavior in rats. [ Methods] A total of 40 Spague Dawley rats weighed 60 -80 g, male and female each half, were ran domly divided into 4 groups of control, low, middle and high dosage of 0, 25, 100,400 mg/kg. After 16 - week feeding, the rats were tested in Morris water maze for their neurobehavior. [ Results ] In the ac quisition training, the results showed that the escape latency of male rats in middle and high dosage groups were longer than those in control group （ P 〈 0.05 ） , while the female rats did not show this effect on them. In prob triM, average movement speed in female rats of three groups were significantly different from that in those of control group { P 〈 0.05 } ; activity time in target quadrant and peripheral zone of platform were sig- nificantly lower in the three dosage groups than that in control group with both male and female rats { P 〈 0.05）. [ Conclusion ] The result shows Triazoohos exoosure can decrease the neurnhe.havior in rats