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环周切缘阳性、LYVE-1表达对直肠癌患者预后的判断价值 被引量：1

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摘要 目的探讨淋巴管内皮透明质酸受体-1(LYVE-1)的表达及环周切缘阳性与直肠癌预后的关系。方法通过病理学检查评价98例直肠癌患者直肠系膜环周切缘情况,运用免疫组化方法检测LYVE-1在直肠癌的表达,并观察二者与直肠癌临床病理参数的关系。结果 LYVE-1的阳性产物表达于淋巴管内皮细胞胞质中,呈棕黄色染色,主要集中于癌组织边缘和正常黏膜的交界处。中、低分化直肠癌Ⅲ～Ⅳ期LYVE-1表达明显高于Ⅰ～Ⅱ期(P<0.05),有淋巴结转移者明显高于无淋巴结转移者(P<0.01)。有淋巴结转移者环周切缘癌细胞阳性率高于无淋巴结转移者(P<0.05),肿瘤下缘距齿线距离<5 cm者环周切缘癌细胞阳性率高于≥5 cm者(P<0.05)。结论联合检测直肠癌LYVE-1表达及环周切缘有助于预测患者术后的局部复发及远处转移。
作者 冯起放 刘晓平 吴平辉 苏晋捷 曾翔辉
机构地区 赣南医学院第一附属医院
出处 《山东医药》 CAS 2013年第13期50-51,共2页 Shandong Medical Journal
基金 赣州市科技局指导性科技计划项目(赣市科发20112529)
关键词 直肠肿瘤 环周切缘 淋巴管内透明质酸受体-1
分类号 R735.37 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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共引文献7

同被引文献10

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山东医药
2013年 第13期

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