摘要
用均相成核理论分析了超临界CO2 快速膨胀法(RESS)制备灰黄霉素微细颗粒过程中的预膨胀操作。指出在类似于灰黄霉素这样在反常冷凝区进行的RESS过程,预膨胀段的加热不会导致溶质灰黄霉素在预膨胀段提前析出。
The pre expansion operation of rapid expansion of supercritical solution (RESS) is investigated by classical homogeneous nucleation theory in this article. Griseofulvin will not deposit from the supercritical CO 2 even though the supersaturation increases with the increasing pre expansion temperature. Otherwise, the lower pre expansion pressure results in higher nucleation rate. Therefore, high pre expansion temperature can be chosen when higher pre expansion pressure is set.
出处
《华东理工大学学报(自然科学版)》
EI
CAS
CSCD
北大核心
2000年第1期18-20,共3页
Journal of East China University of Science and Technology
关键词
超临界
灰黄霉素
晶粒细化
溶液体速膨胀
supercriticality
homogeneous nucleation
crystallization
griseofulvinum
grain refinement