超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀

Preexpansion of Fine Griseofulvin Particle Formation by Rapid Expansion of Supercritical Solution

用均相成核理论分析了超临界ＣＯ２ 快速膨胀法（ＲＥＳＳ）制备灰黄霉素微细颗粒过程中的预膨胀操作。指出在类似于灰黄霉素这样在反常冷凝区进行的ＲＥＳＳ过程，预膨胀段的加热不会导致溶质灰黄霉素在预膨胀段提前析出。

The pre expansion operation of rapid expansion of supercritical solution (RESS) is investigated by classical homogeneous nucleation theory in this article. Griseofulvin will not deposit from the supercritical CO 2 even though the supersaturation increases with the increasing pre expansion temperature. Otherwise, the lower pre expansion pressure results in higher nucleation rate. Therefore, high pre expansion temperature can be chosen when higher pre expansion pressure is set.