关木通中的苯丙素成分研究

Phenylpropanoids from Aristolochia Manshuriensis Kom.

首次从关木通(AristolochiamanshuriensisKom.)的乙酸乙酯提取物中分离出7个苯丙素类化合物,其中两个为8-O-4′新木脂素:1-(4-羟基-3-甲氧基-苯基)-2-{2-甲氧基-4-[1-(E)-丙烯-3-醇]-苯氧基}-丙烷-1,3-二醇(赤式)(1),1-(4-羟基-3-甲氧基-苯基)-2-{2,6-二甲氧基-4-[1-(E)-丙烯-3-醇]-苯氧基}-丙烷-1,3-二醇(赤式)(2);另外5个为苯丙素甙:6-O-(E)-对羟基桂皮酰基-葡萄糖(3),6-O-(E)-阿魏酰基-葡萄糖(4),6-O-(E)-对羟基桂皮酰基-乙基-葡萄糖甙(5),6-O-(Z)-对羟基桂皮酰基-乙基-葡萄糖甙(6),3-O-(E)-对羟基桂皮酰基-葡萄糖(7).化合物1～7均是首次从马兜铃属植物中得到,其中1,5,6为新的天然产物,并考察了这些化合物清除羟基自由基和DPPH自由基的活性.

Two neolignans and five phenylpropanoid glycosides were isolated from the ethyl- acetate extract of stemsof Aristolochia manshuriensis.Their structures were elucidated as 1 - (4 - hydroxy- 3 - methoxyphenyl) - 2 - { 2 - methoxy- 4- [1 - (E) - propen- 3 - ol]- phenoxy} - propan- 1 , 3 - diol(erythro) (1 ) ,1 - (4 - hydroxy- 3 - methoxyphenyl) - 2 - { 2 ,6- dimethoxy- 4- [1 - (E) - propen- 3 - ol]- phenoxy} - propan- 1 ,3 - diol (erythro) (2 ) ,6- O- (E) - p - hydroxy- cinnamoyl- glucose (3 ) ,6- O- (E) - feruloyl- glucose (4 ) ,6- O- (E) - p - hydroxy- cinnamoyl- ethyl- glucoside (5) ,6- O- (Z) - p - hydroxy- cinnamoyl- ethyl- glucoside(6) ,3 - O- (E) - p - hydroxy- cinnamoyl- glucose (7) .All of them were isolated from Aristolochiaceae for the first time and compounds1 ,5 and 6were new natural products.Furthermore,3～ 7have shown the bioactivity of scaveng- ing·OH,5and6exhibited a relatively higher scavenging ability.