突发性耳聋病程与疗效相关关系的研究

The relationship between course of disease and therapeutic effect in sudden deafness

目的探讨突发性耳聋的最佳治疗时间点和治疗的预期结果。方法收集病程2周内的371例突发性耳聋患者,行常规治疗方法治疗,并根据不同病程和患者的不同年龄、不同听力损失及是否伴有眩晕分组观察其疗效。结果病程在6 d以内治疗的总有效率达100%,以后各时间段内疗效均有下降,组间差异显著;在不同的病程和不同的年龄中,年龄≤35岁者各时间段总有效率均为100%,>35岁者各组总有效率有下降,下降的各组间有显著性差异;在听力损失患者中,轻度、中度、重度和全聋的总有效率随着时间呈渐进式下降的态势,其下降的组间有显著性差异;伴有眩晕的患者中,在病程>6 d就诊者疗效开始下降,下降的各组间有显著性差异。而未伴有眩晕的患者在10 d后就诊者疗效下降,但下降的组间无显著性差异。结论突发性耳聋最佳的治疗时间点为6 d以内,其疗效与患者的病程、听力损失以及是否伴有眩晕有关,对突发性耳聋患者需要及时、正确的进行治疗。

Objective The explore the best treatment time points for sudden deafness and the expected results. Methods The 371 cases of sudden deafness with the course of two weeks were collected and treated with conventional treatment; their efficacy were evaluated depending on the different course, different ages and different degree of hearing loss as well with or without dizziness. Results In group of course within 6 days, the total effective rate was 100%; during subsequent points efficacy were decreased at the different groups, the differences were distinct among the different groups. Among the patients aged less 35 years at each time point and different pathogenesis total effective rate was 100%, the rate was declined with the age over 35 years, falling significantly, the differences were distinct among the different groups. The total effective rate in the patients with hearing loss, mild, moderate, severe, and whole deafness was progressive decline with time trend, the decline had significant difference among declined groups. The efficacy was decreased for the vertigo patients with the course of more than 6 days. The differences among groups were distinct. The efficacy was decreased for the patients not associated with vertigo after 10 days down, but the decline had no differences among these groups. Conclusion The optimal treatment time of sudden deafness was within 6 days. Its efficacy depends on the patient＇s pathogenesis, hearing loss and whether accompanied by dizziness,the sudden deafness patients need timely and proper treatment.