AECOPD患者凝血功能变化及中医证候特点

Relationship between Blood Coagulation Function Imbalance and Syndrome Patterns of TCM in AECOPD

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者凝血功能变化及中医证候特点。方法将AECOPD患者分为痰热腑实证、谈浊蕴肺证及阴虚证。入院后第1日晨检测患者血常规、血气分析及凝血指标,分析AECOPD实验室指标及中医证候特点。结果 AECOPD痰热腑实证患者纤维蛋白原、纤维蛋白降解产物及D-二聚体均明显升高,抗凝血酶-Ⅲ明显下降。凝血酶原时间、凝血活酶时间、活化部分凝血活酶时间及血小板无明显变化。结论 AECOPD痰热腑实证者表现为高凝状态,治疗中在祛痰清热同时,加用养阴凉血、活血祛瘀之品,以改善凝血功能。

Objective： To investigate the relationship between blood coagulation function imbalance and syndrome patterns of TCM in AECOPD.Methods： 108 AECOPD patients were divided randomly into different groups according to different syndrome pattern.On the next morning after in-patient,blood coagulation function targets were detected.Some indices were analyze the blood coagulation function change and the character of syndrome pattern.Results： In the AECOPD patient with Tanrefushi syndrome,these indicators were significantly higer such as fibrinogen,fibrinogen degradation products and D-dimmer.However,the antithrombin III was significantly lower in this syndrome.There were no obvious differences in these indices including prothrombin time,thromboplastin time,activated partial thromboplastin time and the number of platelets.Conclusion： AECOPD patients with Tanrefushi syndrome pattern exist the dysfunctions of coagulation.When we treat it with methods of the Qutanqingre,the Yangyinliangxue and Huoxuehuayu herbs to improve the coagulation function.