甲磺酸多沙唑嗪热氧降解历程与动力学研究

The Thermal Oxidation Degradation Process and Kinetics of Doxazolazine Methylsulfonate

用热重法（ＴＧ）、微分热重法（ＤＴＧ）、和差热分析法（ＤＴＡ）研究药物甲磺酸多沙唑嗪（Ｃ_２４Ｈ_２９Ｎ_５Ｏ_８Ｓ）在空气流中的热氧降解过程和热气降解动力学，发现该药物的热氧降解过程由４个紧连步骤组成。用Ｃｏａｔｓ－Ｒｅｄｆｅｒｎ方程进行动力学处理，确定该药物热氧降解的表观反应级数分别为１．１、１．５、１．５、１．２和反应活化能为３５３．７，２３９．５，２２９．９和１６７．２ ｋＪ／ｍｏｌ。

DTA and TG/DTG techniques were used to study the thermal oxidation degradation process and kinetics of doxazolazine methylsulfonate in air. It was found that the thermal oxidation degradation process of doxazolazine methylsulfonate is in four steps. kinetic treatment with Coats-Redfem equation showed that the apparent degradation reaction orders are 1. 1, 1.5, 1.5, 1.2 and the activation energies are 363 .7, 239.5, 229.9 and 167.2 kJ/mol, respectively.