脑钠肽与急性冠脉综合征的相关性研究

Research on the Correlation between Brain Natriuretic Peptide and Acute Coronary Syndrome

目的:通过对外周血中B型脑钠肽的浓度水平来评定急性冠脉综合征患者的血管病变程度.方法:选择2010年12月～2013年1月在内蒙古民族大学附属医院住院的资料完整的中老年冠心病患者90例,年龄均大于56岁,平均年龄大约在(56±6)岁,其中正常对照组30例,不稳定心绞痛(UA)30例,心肌梗死(AMI)30例,所有患者均行冠状动脉造影术或256排螺旋CT确诊.结果:90例老年冠心病患者中,急性心肌梗死组的因子浓度水平明显高于不稳定心绞痛组,而不稳定心绞痛组明显高于正常组.结论:说明因子浓度越高,冠状动脉血管病变越严重.

Objective： To evaluate the vascular lesion degree of patients with acute coronary syndrome through detect- ing the B-type brain natriuretic peptide levels in peripheral blood. Methods： The intact data of 90 middle and elderly aged patients with coronary heart disease who hospitalized in the Affiliated Hospital of Inner Mongolia University for Nationalities from December 2010 to April 2013 were selected, their age were all more than 56 years and the average was about 56 ~ 6. The normal control group, the unstable angina （UA） group and the acute myocardial infarction （AMt） group each had 30 patients, all the patients were diagnosed by coronary angiographyor or 256-slice spiral CT. Results： In 90 elderly patients with coronary artery disease, the brain natriuretic peptide levels in AMI group was sig- nificantly higher than that of UA group, and the levels in UA group was significantly higher than that of normal group. Conclusion： The level of brain natriuretic peptide can reflect the degree of vascular lesion, and the higher concentra- tion of the factor, the more serious of coronary artery disease.