楚雄州中医院2011年细菌耐药性监测结果分析

Surveillance of Bacterial Resistance in the Chinese Medicine Hospital of Chuxiong Prefecture in 2011

目的:了解2011年临床分离菌株对常用抗生素的耐药性。方法:采用API鉴定和ATB药敏板条及纸片扩散法对2011年临床分离1 127株细菌进行药敏试验。结果:1 127株细菌中革兰阴性菌占76.8%,革兰阳性菌占23.2%。革兰阴性菌中前3位为大肠埃希菌45.7%(395/865)、肺炎克雷伯菌10.6%(92/865)和铜绿假单胞菌9.0%(78/865);革兰阳性菌中前3位为屎肠球菌27.1%(71/262)、金黄色葡萄球菌24.8%(65/262)和表皮葡萄球菌16.0%(42/262)。药敏试验结果显示泛耐药铜绿假单胞菌和不动杆菌检出率分别为19.2%(15/78)和32.8%(23/70);MRSA和MRCNS分别占金黄色葡萄球菌和CNS的32.3%(21/65)和83.3%(40/48)。结论:定期进行耐药性监测有助于了解细菌耐药性的变迁,为临床用药提供依据。

Objective： To investigate the resistance of clinical isolates in the Chinese Medicine Hospital of Chuxiong Prefecture in 2011. Methods： Antimicrobial susceptibility testing of 946 clinical isolates were carried out by Kirby-Bauer （K-B） method and microdilution method. Results： Among the 1 127 clinical isolates, gram-negative bacteria and gram-positive bacteria accounted for 76.8% and 23.2%, respectively. In 865 gram negative bacillis, E. coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. accounted for 45.7% （395/865）, 10.6%（92/865） and 9.0%（78/865）, respectively. In 262 gram positive cocci, E. faecium, S. aureus and Staphylococcus epidermidis, accounted for 27.1% （71/262）, 24.8% （65/262） and 16.0%（42/262）. Susceptibility test results showed that Pseudomonas aeruginosa and Acinetobacter spp. were detected in 19.2% （15/78） and 32.8% （23/70） pan-resistant strains. The prevalence of emethicillin-resistant Staphylococcus was 83.3% （40/48） in S. aureus and 32.3% （21/65） incoagulase-negative Staphylococcus. Conclusion： Surveillance of bacterial resistance is most important and valuable for guidance of rational selection of antimicrobial agents.