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结直肠癌全基因组关联分析研究进展 被引量：1

Research progress on genome-wide association studies of colorectal cancer
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摘要 结直肠癌是最常见的恶性肿瘤之一,其发生发展是环境和遗传因素共同作用的结果,其中遗传因素在结直肠癌的发病中起重要作用。全基因组关联研究(genome-wide association studies,GWAS)已发现了一些与结直肠癌相关联的易感位点和区域,这有助于结直肠癌遗传机制的研究。文中对近几年来结直肠癌全基因组关联分析的研究进展作一综述,分析GWAS结直肠癌的优点和局限性以及应用前景。 Colorectal cancer （CRC） , one of the most common malignant tumors, is caused both by environmental and genetic factors. Genetic factor plays an important role in the pathogenesis of CRC. Genome-wide association study （GWAS） is a new tool of genetic research. A series of susceptibility genes and loci of the complex diseases has been identified with GWAS strategy. In this article, the research progress on GWAS of CRC is reviewed, and the advantages and limitations of GWAS study as well as the prospective of its application are discussed.
作者 张艳 来茂德 朱益民
机构地区 浙江大学医学院流行病与卫生统计学系 病理学与病理生理学系
出处 《浙江大学学报（医学版）》 CAS CSCD 北大核心 2013年第3期360-366,共7页 Journal of Zhejiang University(Medical Sciences)
基金 国家自然科学基金(81172755) 浙江省自然科学基金(D2080011) 中央高校基本科研业务费专项资金资助(2011XZZX004)
关键词 多态性 单核苷酸 结直肠肿瘤 遗传学 疾病遗传易感性 基因组 Polymorphism, single nucleotide Colorectal neoplasms/genetics Genetic predispositionto disease Genome
分类号 R735.3 [医药卫生—肿瘤]
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参考文献38

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浙江大学学报（医学版）
2013年 第3期

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