期刊文献+

核质转运通路及其抑制剂在肿瘤靶向治疗中的研究进展

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摘要 0引言恶性肿瘤是世界范围内死亡率较高的疾病,并有逐年上升的趋势。尽管近年来不断涌现出新的抗肿瘤药物,但肿瘤的高复发性和耐药性仍不可避免肿瘤细胞的恶性增殖与一系列信号转导通路的异常激活或抑制密切相关。其中转录因子及转录辅助因子,通过核孔复合体(nuclear pore complexes,
作者 颜文青 侯健
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2013年第6期517-520,共4页 Cancer Research on Prevention and Treatment
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参考文献34

  • 1Cohen-Fix O. Cell biology: Import and nuclear size[J]. Na- ture, 2010, 468(7323):513-6.
  • 2Turner JG, Dawson J, Sullivan DM. Nuclear export of pro- teins and drug resistance in cancer[J]. Biochem Pharmacoh 2(112,83(8) : 1021-32.
  • 3Gasiorowski JZ,Dean DA. Mechanisms of nuclear transport and interventions[J]. Adv Drug Deliv Rev, 2003,55 (6) :703- 16.
  • 4Antoine M, Reimers K, Wirz W, et al. Identification of an unconventional nuclear localization signal in human ribosomal protein S2[J]. Biochem Biophys Res Commun, 2005, 335 ( 1 ) : 146 -53.
  • 5Lee BJ, Cansizoglu AE, Stiel KE, et al. Rules for nuclear lo- calization sequence recognition by karyopherin beta 2[J]. Cell, 2006, 126(3) :543-58.
  • 6Kotera I, Sekimoto T, Miyamoto Y, et al. Importin alpha transports CaMKIV to the nucleus without utilizing importin beta[J]. EMBO J, 2005, 24(5):942-51.
  • 7Nakielny S, Dreyfuss G. Import and export of the nuclear pro- tein import receptor transportin by a mechanism independent of GTP hydrolysis[J]. Curr Biol, 1998, 8(2) :89-95.
  • 8Fagotto F, Gluck U, Gumbiner BM. Nuclear localization signal-independent and importin/karyopherin-independent nuclear im- port of beta-catenin[J]. Curr Biol, 1998, 8(4) : 181-90.
  • 9Sachdev S, Bagchi S, Zhang DD, et al. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway[J]. Mol Cell Biol, 2000, 20(5):1571-82.
  • 10Terry LJ, Shows EB, Wente SR. Crossing the nuclear enve- lope: hierarchical regulation of nucleocytoplasmic transport [J]. Science, 2007, 318(5855):1412-6.

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