髓系肉瘤的临床特征和生存分析

Clinical Manifestation and Survival Analysis with Myeloid Sarcoma

目的探讨髓系肉瘤(myeloid sarcoma,MS)患者的临床特征、治疗方法和预后。方法回顾性分析17例髓系肉瘤患者的临床特征和治疗方法,应用Kaplan-Meier法行生存分析。结果 17例髓系肉瘤的发生部位包括淋巴结、乳腺、宫颈、眼眶等。孤立性髓系肉瘤8例,白血病性髓系肉瘤9例。MS的1年和3年总生存率为(72.0±12.0)%、(45.7±14.4)%。孤立性和白血病性髓系肉瘤3年生存率分别为(85.7±13.2)%、(51.9±17.6)%。结论孤立性髓系肉瘤较白血病性髓系肉瘤生存有更好的趋势。髓系肉瘤的生存与髓系疾病的类型及不良预后因素也有关。

Objective To investigate the clinical manifestations, treatment and prognosis of myeloid sarco ma（MS）. Methods Clinical data of 17 MS cases were retrospectively analyzed. Survival analysis was made by Kaplan-Meier method. Results The predilection sites had lymph nodes, breast, cervix and orbit. Eight cases of isolated myeloid sarcoma and 9 case leukemia myeloid sarcoma were observed. The overall survival rate at 1 year was （72. 0 ± 12. 0） %and 3 years （45.7 ± 14. 4） %. The overall survival rate of 3 year in isolated myeloid sarcoma was （85.7± 13.2）%, and （51.9 ± 17. 6）%in leukemia. Conclusion Prognosis in isolated myeloid sarcoma was better than that in leukemia myeloid sarcoma. Survival of mye- loid sarcoma was related to types of disease and adverse prognostic factors