男性帕金森病患者性功能障碍的初步调查

Male sexual dysfunction and Parkinson’s Disease:A preliminary investigation

目的:观察男性帕金森病(PD)患者性功能障碍的发生率,探讨其发生机制和相关因素。方法:采用简易智能精神状态检查表(MMSE)、统一帕金森病评分量表第三部分(UPDRSⅢ)、Hoenhn-Yahr分期(H&Y stag-ing)、汉密尔顿抑郁量表(HAMD)和WHO国际疾病分类第10版性功能障碍诊断标准对140例男性PD患者进行评估,所有PD患者完成了左旋多巴等效剂量(LED)的换算。结果:140例PD患者中,58例存在性功能障碍,发生率为41.43%。PD患者性功能障碍组和无性功能障碍组比较,两组间年龄、受教育程度、起病时间、病程、UPDRSⅢ、H&Y分期和LED没有差异;性功能障碍组HAMD得分(14.95±9.12)分,无性功能障碍组为(10.96±9.82)分,两组间比较差异有统计学意义(P<0.05)。PD患者性功能障碍的发生和PD患者HAMD得分相关,差异有统计学意义(P<0.05)。结论:性功能障碍是PD患者常见的非运动症状,PD患者抑郁程度和PD患者性功能障碍的发生呈正相关。

Objective： To investigate the prevalence of male sexual dysfunction in males with Parkinson＇s disease and the pathogenesis and related factors of the problem. Methods： We evaluated the sexual function of 140 men with Parkinson＇s disease using Mini-mental State Examination （MMSE）, Unified Parkinson＇s Disease Rating Scale （Part Ⅲ ） （UPDRS HI ）, Hoenhn-Yahr Staging （HYS）, Hamilton Depression Scale （HAMD） and Sexual Dysfunction Standard of ICD-10. We calculated the Levodopa equivalent doses （LED） for all the patients. Results ： Sexual dysfunction was found in 58 （41.43%） of the patients with Parkinson＇s disease. There were no significant differences in age, education, age of onset, course of disease and scores on UPDRS Ⅲ, HYS and LED between the sexual dysfunction and normal sexual function groups. The HAMD score was 14.95 ± 9.12 in the sexual dysfunction group, significantly higher than 10.96 ± 9.82 in the normal sexual function group （P 〈 0.05 ）, and it was positively correlated with the incidence of male sexual dysfunction （ P 〈 0.05 ）. Conclusion ： Sexual dysfunction is a common symptom in males with Parkinsong disease, and is correlated with the high HAMD score of Parkinsong disease patients.