模拟寒潮对高血压疾病影响机理的实验研究

Study of Influence Mechanism of Cold Wave on Hypertension Disease

文章通过动物实验初步探讨了模拟寒潮对高血压疾病影响的机理。采用统计降尺度方法建立了模拟寒潮模型,应用TEM1 880气象环境模拟箱模拟寒潮温度和气压变化,将SHR和Wister大鼠低温组、回温组放人模拟箱内,使其受寒潮天气影响,按照寒潮天气过程发生的不同时间先后分批取出实验大鼠,测量各组大鼠的收缩压(SBP)、心率(HR)、体重,并通过腹主动脉采血测量肾上腺素(EPI)、血管紧张素Ⅱ(AngⅡ)及全血粘度(WBV)等。实验结果分析表明,受模拟寒潮天气影响大鼠SBP、HR、EPⅠ、AngⅡ和WBV比对照组高;除Wister大鼠HR外,其他指标均是SHR组受到影响大于Wister组;除EPI和WBV回温组受寒潮影响高于低温组外,其余指标低温组均高于回温组。模拟寒潮刺激使HR、EPⅠ、AngⅡ和WBV升高,这些指标的升高导致SBP升高,对高血压疾病产生影响。

Based on the animal experiments, the influence mechanism of cold wave on hypertension was dis- cussed in this paper. The cold wave models were established by statistical downscaling method, and the cold wave processes were simulated in the meteorological environment simulation chamber （TEM1880）. At the same time, the SHR and Wister rats were put into simulation chambers divided into low-tempera- ture group and return-temperature group and subjected to the progresses of cold wave respectively. The following indexes were measured on experimental rats in batches in accordance with the process of cold wave process that occurred in different times： systolic blood pressure （SBP）, heart rate （HR）, weight, epinephrine （EPI）, angiotensin Ⅱ （Ang Ⅱ ） and whole blood viscosity （WBV）. The results are as follows：compared with the control-group, SBP, HR, EPI, Ang Ⅱ and WBV of the experimental-group subjected to cold wave are higher. Except HR, the other physiological indexes of SHR group are more sensitive than the ones of Wister group. The indexes of low-temperature group are higher than return-temperature group except EPI and WBV. Cold waves can elevate HR, EPI, AngⅡand WBV which lead to a higher SBP so that it has a great impact on hypertension.