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QGY-7701肝癌细胞株中癌-睾丸抗原GAGE-1基因的表达 被引量：2

The mRNA Expression of Cancer-Testis Antigen GAGE-1 Gene in Hepatocellular Carcinoma Cell Line QGY-7701
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摘要 目的研究癌-睾丸抗原GAGE-1基因mRNA在QGY-7701肝癌细胞株中的表达情况。方法运用反转录聚合酶链反应技术检测肝癌细胞株QGY-7701中GAGE-1基因mRNA的表达,并与正常肝组织比较。结果肝癌细胞株QGY-7701中GAGE-1基因呈阳性表达,正常肝组织中GAGE-1基因呈阴性表达。结论 GAGE-1基因具有作为诊断肝癌的分子标记和免疫治疗肝癌的特异性靶位的潜在价值。 Objective To investigate the mRNA expression of cancer-testis antigen GAGE-1 gene in hepatocellular carcinoma（HCC） cell line QGY-7701. Methods Reverse transcription-polymerase chain reaction （RT-PCR） was used to test the mRNA expression of HCC cell line QGY-7701 which was compared with that of normal liver tissue. Results GAGE-1 gene mRNA was of positive expression in HCC cell line QGY-7701 but of negative expression in normal liver tissue. Conclusion GAGE-1 gene can be used as molecular markers for early diagnosis and possible targets for immunotherapy of human HCC.
作者 农彩莲 李立志 范蓉 何国珍 李中华 岑妍慧 黄荣师 陈青 赵飞兰
机构地区 广西天等县人民医院 广西民族医院普外科 广西中医药大学组胚教研室
出处 《广西医学》 CAS 2013年第5期521-523,共3页 Guangxi Medical Journal
基金 国家自然科学基金(81260313/H1604) 广西自然科学基金(2011GXNSFB018086) 广西教育厅立项项目(200710LX025)
关键词 肝癌 癌-睾丸抗原 QGY-7701肝癌细胞株 GAGE-1基因 反转录聚合酶链反应 Hepatocellular carcinoma Cancer-testis antigen Hepatocellular carcinoma cell line QGY-7701 GAGE-1 gene Rverse transcription-polymerase chain reaction
分类号 R735.7 [医药卫生—肿瘤]
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参考文献9

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二级参考文献34

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广西医学
2013年 第5期

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