摘要
以3-硝基-2-羧基苯甲酸乙酯为起始原料,以五氯化磷为酰卤化剂,二氯甲烷为反应溶剂合成了3-硝基-2-氯甲酰基苯甲酸乙酯,产率达到95%.此方法简单方便,提高了产率,更适合工业化生产.
2 - Chloroformyl - 3 - nityl ethyl benzoate is synthesized via reaction of aeyl chloride uising 2 -earboxyl- 3 -nityl ethyl benzoate as the stating material. Phosphorus pentachloride is used as the acyl chloride agent, diehloromethane is used as the solvent in yield 95 %. The structure of product is confirmed by H NMR. This method is simple to operate with cost and high yield and is also more suitable for the large scale production.
出处
《哈尔滨师范大学自然科学学报》
CAS
2012年第6期52-53,共2页
Natural Science Journal of Harbin Normal University
基金
哈尔滨师范大学大学生创新实践项目
哈尔滨师范大学大学生实践创新团队项目
关键词
坎地沙坦
合成
中间体
改进
Candsartant
Synthesis
Intermediate
Improvement
