培菲康联合四联疗法治疗难治性幽门螺杆菌感染54例疗效观察

Observation on the effect of probiotics coupled with quadruple therapy in 54 cases infected with refractory helicobacter pylori

目的探讨益生菌在治疗难治性幽门螺杆菌(Hp)感染中的价值。方法 106例Hp感染慢性胃炎患者经三联根治疗法治疗失败后经患者知情同意按治疗方法分成益生菌治疗组和对照组。治疗组54例给予培菲康+四联疗法,对照组52例单给四联疗法,比较2组Hp根除率及不良反应发生情况。结果治疗组的Hp根除率(88.9%)明显高于对照组(71.2%),差异有统计学意义(P<0.05);同时治疗组不良反应发生率(11.1%)明显低于对照组(26.9%),差异有统计学意义(P<0.05)。结论益生菌能有效提高难治性Hp的根除率,减少药物的不良反应。

Objective To explore the value of probiotics in the treatment of refractory helicobacter pylori （HP） infection. Methods One hundred and six cases of chronic gastritis, which failed to respond to triple radical treatment, were randomly divided into 2 groups, i.e. the probiotics treatment group and the control group. Fifty-four cases in the treatment group were treated with probi- otics combined with quadruple eradication therapy, while 52 cases in the control group were only given quadruple eradication therapy. Then, the rate of HP eradication and side effects were compared between the 2 groups. Results Results indicated that the rate of HP e- radication （ 88.9% ） in the probiotics treatment group was obviously higher than that （71.2%） of the control group, with statistical significance （ P 〈 0.05 ）. Meanwhile, the rate of side effects in the treatment group （ 11.1% ） was considerably lower than that of the control group（26.9% ） , also with statistical significance （ P 〈 0.05 ）. Conclusion Probiotics could effectively increase the rate of re- fractory HP eradication and decrease the rate of side effects.