一种山奈酚环糊精包合物的制备

Preparation of kaempferol cyclodextrin complex

目的制备难溶性药物山奈酚一种环糊精包合物,提高山奈酚的溶解度,拓宽山奈酚的给药途径。方法利用研磨法制备山奈酚羟丙基-β-环糊精、山奈酚β-环糊精包合物,通过粉末X射线衍射分析、差示扫描量热分析和红外光谱分析等方法对制备的山奈酚环糊精包合物进行鉴定和表征分析。结果山奈酚与羟丙基-β-环糊精、β-环糊精分别形成了包合物,包合前后水溶解性考察表明形成包合物后山奈酚的溶解度分别增加了26.7与9.7倍。结论山奈酚环糊精包合物的制备方法简捷实用,达到了增加药物溶解度的目的 ,有助于山奈酚的进一步开发利用。

Objective To prepare the hard-to-dissolve kaempferol-β-cyelodextrin complex and to increase the solubility of kaempferol, so as to broaden the ways of kaempferol medication. Methods Trituration was used to prepare kaempferol- hydroxypropyl- β-cyclodextrins and the kaempferol-β-cyclodextrin complex. The PXRD, differential scanning calorimetry （DSC） and infrared spectrom- etry （IR） were used to identify and characterize the prepared complex. Results Complexes were derived respectively from kaempferol, hydroxypropyl-β-cyclodextrins, andβ-cyclodextrin. Solubility research both before and after the formation of the complexes showed that the solubility of kaempferol after the formation of the complex increased by 26.7 and 9.7 times respectively. Conclusion The prepara- tion method of kaempferol-β-cyclodextrin complex was simple and practical, and could enable further development and application of kaempferol.