血清骨保护素和糖化血红蛋白水平与急性冠状动脉综合征的关系探讨

Relationship between serum osteoprotegerin and glycated hemoglobin levels in patients with acute coronary syndrome

目的:探讨血清骨保护素(OPG)和糖化血红蛋白(HbA1c)水平与急性冠状动脉综合征(ACS)的关系。方法:将88例住院患者分为对照组、稳定性心绞痛(SAP)组和ACS组,于入院时检测3组患者血浆OPG和HbA1c水平并进行冠状动脉造影。根据造影结果分为1支、2支、3支病变组并分析各组与冠状动脉病变Gensini评分的相关性。结果:ACS组患者OPG和HbA1c水平均高于对照组(P<0.01),且随病变支数的增加而升高(P<0.05～P<0.01)。OPG与冠状动脉病变Gensini评分间呈显著正相关关系(P<0.01);HbA1c与冠状动脉病变Gensini评分也呈正相关关系(P<0.01)。OPG与HbA1c呈显著正相关关系(P<0.01)。结论:血清OPG和HbA1c水平的升高与ACS病变程度有关。

Objective： To analyze the relationship between serum osteoprotegerin（OPG） and glycated hemoglobin（HbA1c） levels in patients with acute coronary syndrome（ACS）.Methods： Eighty-eight patients were classified into control group,stable angina pectoris（SAP） group and ACS group.Serum OPG and HbA1c levels were measured upon hospital admission and divided into 1-,2-,3-vessel disease groups according to the numbers of narrowed coronary vessels under coronary angiography.The relationships of serum OPG and HbA1c levels and coronary stenosis degree according to Gensini score were analyzed.Results： Serum OPG and HbA1c levels in ACS group were significantly higher than in control group（P 0.01）,and OPG and HbA1c levels were increased significantly with the severity degree of ACS（P 0.05-P 0.01）.A positive relationship was found between OPG level and Gensini score（P 0.01）,and a positive correlation was also found between HbA1c level and Gensini score（P 0.01）.OPG level was positively correlated with HbA1c level（P 0.01）.Conclusions： Serum OPG and HbA1c levels were related with the severity of ACS.