细菌非编码小RNA的分类及功能简介

CLASSIFICATIONS AND FUNTIONS OF SMALL NON-CODING RNA IN BACTERIA

细菌非编码小RNA（non-coding small RNA,简称sRNA）是一类长度为40~500个核苷酸,在基因组中被转录但不编码蛋白质的一类RNA分子。它们大多数在Hfq的协助下,通过碱基配对识别靶标mRNA,在转录后水平调节基因的表达,是细菌代谢、群体感应和适应环境变化及毒力基因表达的重要调节因子。本文对sRNA的分类及功能作如下综述。

Non-coding RNAs in bacteria（sRNAs） are RNAs of about 40-500 nucleotides that transcribe but don＇t encode proteins.Most of these sRNAs act through base-pairing with target mRNAs with help of Hfq,resulting in post-transcriptionally regulating gene expression.Therefore,sRNAs are important regulators in bacterial metabolism,quorum sensing,adaption to environmental change and virulence gene expression.