3种不同化疗方案二线治疗复发性卵巢癌的对比研究

Comparative Study of Three Chemotherapy Regimens of in the Second-line Treatment of Recurrent Ovarian Cancer

目的分析3种不同化疗方案二线治疗复发性卵巢癌的疗效和安全性,探讨复发性卵巢癌治疗适宜的二线化疗方案。方法 78例复发性卵巢癌患者分为3组,A组:30例,吉西他滨1.0 g.m-2,d1,8;顺铂75 mg.m-2,d1,21 d为1周期。B组:23例,伊立替康180 mg.m-2,d1;顺铂75 mg.m-2,d1,21 d为1周期;C组:25例,多西他赛75 m g.m-2,d1;顺铂75 m g.m-2,d1,21 d为1周期。结果 3种治疗方案的有效率分别为60.0%、56.5%、64.0%(P>0.05)。3组患者的毒副反应均可耐受,A组血小板减少Ⅲ、Ⅳ度以上的发生率稍高,为16.7%;B组Ⅱ、Ⅲ度迟发性腹泻的发生率稍高,为17.4%;C组Ⅱ、Ⅲ度脱发的发生率稍高,为68.0%。结论 3种化疗方案二线治疗复发性卵巢癌的疗效相当,毒副反应均可以耐受。

Objective To compare the efficacy and toxicities of three chemotherapy regimens in the second-line treatment of recurrent ovarian cancer, and to investigate the suitable second-line chemotherapy regimen for recurrent ovarian cancer. Methods The 78 recurrent patients with ovarian cancer were divided into three groups. In the group A： 30 patients received the gemcitabine-cisplatin chemotherapy, gemcitabine 1.0 g·m^-2, d1.8; cisplatin 75 mg·m^-2, d1, 21 days were 1 cycle. In the group B： 23 patients received the irinotecan-cisplatin chemotherapy, irinotecan 180 mg·m^-2, d1 ; cisplatin 75 mg·m^-2, d1 , 21 days were 1 cycle. In the group C： 25 patients received docetaxel-cisplatin chemotherapy, docetaxel 75 mg·m^-2, d1 ; cisplatin 75 mg·m^-2 , d1, 21 days were 1 cycle. Results The overall response rate of the three regimens was 60.0%, 56.5%, 64.0%, respectively （ P 〉 0.05）. The toxicities were tolerable for the three regimens. Grade Ⅲ/Ⅳ thrombocytopenia （ 16.7% ） was more frequent in the group A. Grade Ⅱ/Ⅲ delayed-onset diarrhea （17.4%） was more frequent in the group B. Grade Ⅱ / Ⅲ alopecia （68.0%） was more frequent in the group C. Conclusion These three regimens showed similar efficacy in the second-line treatment of recurrent ovarian cancer, the toxicities of three regimens were tolerable.