期刊文献+

后肢去负荷干预后不同时间的跑台训练对大鼠股骨骨密度和骨代谢指标的影响 被引量:6

Effect of Treadmill Training at Different Time after Hindlimb Unloading on Bone Mineral Density of Rat Femurs and Markers of Bone Metabolism
原文传递
导出
摘要 目的:研究后肢去负荷干预后不同时间的跑台训练对大鼠股骨骨密度和骨代谢指标的影响。方法:9周龄Wistar雌性大鼠64只随机分为8组,每组8只。Group 1:尾部悬吊4周,处死;Group 2和Group3:尾部悬吊4周,之后分别跑台训练4周和8周,处死;Group 4和Group 5:尾部悬吊4周,之后分别自由活动4周和8周,处死;Group 6、Group 7和Group 8:正常饲养,不进行尾部悬吊,分别于分组4周后、8周后和12周后处死。测试各组大鼠股骨骨密度和血清骨代谢指标。结果:与其对应周龄的阴性对照组相比,尾部悬吊组大鼠血钙和抗酒石酸酸性磷酸酶5b显著升高,血清碱性磷酸酶和骨钙素无显著差异,骨密度显著降低;恢复正常活动后,大鼠血清碱性磷酸酶和骨钙素显著升高,血钙和抗酒石酸酸性磷酸酶5b显著下降,骨密度显著升高;与自由活动组相比,跑台训练组大鼠上述骨代谢指标和骨密度的变化更显著。结论:后肢去负荷导致大鼠骨吸收作用显著增强,使骨密度下降;后肢恢复正常活动后,大鼠的骨形成作用显著增强,并且骨吸收作用也逐渐降至正常水平,骨密度逐渐升高;跑台训练可加速大鼠后肢去负荷干预后骨代谢的改变和骨密度的恢复。 Objective: The purpose of this study is to study the effect of treadmill training at different time after hindlimb unloading on bone mineral density of rat femurs and markers of bone metabolism. Method: Sixty-four Wistar rats aged 9 weeks were used and randomly divided into eight experimental groups : Group 1, the suspended control under hindlimb unloading regimen for 4 weeks, then euthanized ; Groups 2 and 3, the suspended subjected to hindlimb unloading for 4 weeks, followed by treadmill exercise for 4 weeks ( Group 2) or 8 weeks ( Group 3 ) , then euthanized ; Groups 4 and 5, designated free suspended under hindlimb unloading regimen for 4 weeks fol- lowed by free activity in cages for 4 weeks ( Group 4) or 8 weeks ( Group 5 ) , then euthanized ; Groups 6, 7 and 8, negative controls allowed to free activity in cages and euthanized 4, 8 and 12 weeks after grouping respectively. Bone mineral density (BMD) of the left femur and markers of bone metabolism was analyzed. Results : Compared with the rats of corresponding negative control group, serum calcium and tartrate-resistant acid phosphatase 5b of the rat of tail suspension group was significantly elevated, serum alkaline phosphatase and osteoealcin was no sig- nificant difference, bone mineral density was significantly reduced; After returning to normal activity, serum alka- line phosphatase and osteoealcin hormone significantly increased, calcium and tartrate-resistant acid phosphatase 5b significantly decreased, bone mineral density significantly increased; Compared with the free group, the above indicators of bone metabolism and bone mineral density of the treadmill training group changes more significant. Conclusion: hindlimb unloading lead to significantly enhanced bone resorption in rats and decreased bone mineraldensity ; After returning to normal activities, the rat bone formation be enhanced significantly and hone resorption is gradually reduced to normal levels, bone density increased gradually; Treadmill training can accelerate the recovery of bone metabolism changes and bone mineral density after hindlimb unloading intervention.
出处 《北京体育大学学报》 CSSCI 北大核心 2013年第5期64-68,共5页 Journal of Beijing Sport University
基金 山西省高等学校哲学社会科学研究一般项目(20112227) 山西省社科联重点课题研究项目(SSKLZDKT2011053)
关键词 后肢去负荷 康复时间 跑台训练 骨密度 骨代谢 hindlimb unloading rehabilitation time treadmill training bone mineral density bone metabolism
  • 相关文献

参考文献20

  • 1Yokota H, Leong D J, Sun HB. Mechanical loading: bone remodeling and cartilage maintenance [ J]. Curt Osteoporos Rep, 2011, 9(4) :237 -242.
  • 2Lee KC, Lanyon LE. Mechanical loading influences bone mass through estrogen receptor alpha [ J ]. Exerc Sport Sci Rev, 2004, 32(2) :64 -68.
  • 3Hou JC, Salem GJ, Zernicke RF, et al. Structural and mechanical adaptations of immature trabecular bone to strenuous exercise [ J ]. J Appl Physiol, 1990, 69 ( 4 ) : 1309 - 1314.
  • 4Ocarino NM, Marubayashi U, Cardoso TG, et al. Physical activity in osteopenia treatment improved the mass of bones directly and indirectly submitted to mechanical impact [ J ]. J Musculoskelet Neuronal Interact, 2007, 7 ( 1 ) : 84 - 93.
  • 5Ocarino NM, Silva JF, Santiago L, et al. Treadmill train- ing before and/or after ovariectomy is more effective in pre- venting osteopenia in adult female rats [ J ]. Science & Sports, 2009,24( 1 ) :52 -55.
  • 6Veras-Silva AC, Mattos KC, Gava NS, et al. Low-intensi- ty exercise training decreases cardiac output and hyperten- sion in spontaneously hypertensive rats [ J ]. Am J Physi- ol, 1997, 273 (6) : H2627 - 2631.
  • 7Norman TL, Bradley-Popovich G, Clovis N, et al. Aerobic exercise as a countermeasure for microgravity-induced bone loss and muscle atrophy in a rat hindlimb suspension model [ J ]. Aviat Space Environ Med, 2000, 71 (6) : 593 - 598.
  • 8Ip TY, Peterson 1, Bymer R, et al. Bone responses to body weight and moderate treadmill exercising in growing male obese (fa/fa) and lean Zucker rats [J]. J Musculo- skelet Neuronal Interact, 2009, 9 (3) :155 -166.
  • 9Multon S, Franzen R, Poirrier AL, et al. The effect of treadmill training on motor recovery after a partial spinal cord compression-injury in the adult rat [ J ]. J Neurotrau- ma. 2003, 20(8) :699 -706.
  • 10Minaire P. Immobilization osteoporosis : a review [ J ]. Clin Rheumatol, 1989, 2( 1 ) :95 - 103.

同被引文献145

  • 1王晓楠,孙联文,樊瑜波.微重力对骨组织细胞功能的影响[J].中华航空航天医学杂志,2012,23(2):151-156. 被引量:4
  • 2喻鑫罡,张先龙,曾炳芳.低频可控性微动影响长骨骨折愈合的实验研究[J].中华创伤骨科杂志,2005,7(8):744-748. 被引量:24
  • 3李莉,俞红贤,沈明华.不同发育期牦牛血清钙、无机磷和碱性磷酸酶的测定及分析[J].青海大学学报(自然科学版),2007,25(1):70-72. 被引量:11
  • 4刘忠厚.骨质疏松症[M].北京:科学出版社,1998.273-274.
  • 5Miller PD, Jamal SA, Evenepoel P, Eastell R, Boonen S. Renal safety in patients treated with bisphosphonates for osteoporosis: A review. J Bone Miner Res 2013; 28(10): 2049-59.
  • 6McClung M, Harris ST, Miller PD, Bauer DC, Davison KS, Dian L, et al. Bisphosphonate therapy for osteoporosis: Benefits, risks, and drug holiday. Am J Med 2013; 126(1): 13-20.
  • 7Crabtree GR, Olson EN. NFAT signaling: Choreographing the social lives of ceils. Cell 2002; 109 Suppl: $67-79.
  • 8Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, et al. Induction and activation of the transcription factor NFATc 1 (NFAT2) integrate RANKL signaling in terminal differentiation ofosteoclasts. Dev Cell 2002; 3(6): 889-901.
  • 9Takayanagi H. Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immu- no12007; 7(4): 292-304.
  • 10Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, et al. NFAT and Osterix cooperatively regulate bone formation. Nat Med 2005; 11(8): 880-5.

引证文献6

二级引证文献52

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部