右美托咪定在高血压眼科患者术中复合降压的临床研究

Clinical Investigation of Dexmedetomidine Combined with Controlled Hypotension in Hypertensive Ocular Surgery Patients

为了观察右美托咪定在球后神经阻滞麻醉下高血压眼科手术患者中降压的可行性及其效果,选择择期眼科手术的高血压患者40例,随机分为2组[右美托咪定复合硝酸甘油组(D组)和单纯硝酸甘油组(N组)],每组20例。记录患者术前、术中及手术结束时的MAP、SBP、DBP、HR、SpO2及Ramsay评分,同时统计硝酸甘油及右美托咪定用量。结果发现,两组基础MAP、SBP、DBP、HR、SpO2差异无统计学意义(P>0.05),两组降压程度无统计学意义(P>0.05)。组内及组间HR差异有统计学意义(P<0.05)。D组较N组硝酸甘油用量明显减少(P<0.05)。因此右美托咪定可在高血压眼科手术患者中达到较好的镇静及降压效果。

Abstract：To study the effect of controlled hypotension between dexmedetomidine combined with nitroglycerin and nitro- glycerin for ophthalmic surgery, we selected 40 hypertensive patients of ophthalmic surgery which were randomly divided into two groups： group D and group N. MAP, SBP, DBP, HR, SpO2 and Ramsay score were recorded before and after operation. The dosage of nitroglycerin and dexmedetomidine are also recorded. The results are as follows. The basic MAP, SBP, DBP, HR, SpOa, Ramsay score and the decompression degree between two groups have no significant differ- ence（P〈0.05）. The change of HR between-group and intra-group has meaning （P〈0.05）. The dosage of nitroglycer- in in group N is more higher than group D （P〈0.05）. Therefore,we could get better sedation and antihypertensive effica- cy in hypertensive patients who underwent elective ophthalmic surgery and reduce the dosage of nitroglycerin by using dexmedetomidine.