环草石斛化学成分研究

Chemical Components of Dendrobium loddigesii

环草石斛是中医临床上广泛应用的石斛药材。为了进一步研究环草石斛的药效成分,采用硅胶、LH-20凝胶及C-18反相硅胶等柱色谱技术对其甲醇提取液进行了系统分离,结果得到7个化合物,分别是:石斛宁(1),2,4,7-三羟基-9,10-二氢菲(2),2,5-二羟基-4-甲氧基菲(3),loddigesiinols C(4),杓唇石斛酚(5),石斛酚(6),3,4',5-三羟基-3'-甲氧基联苄(7)。这些化合物的结构由质谱、核磁共振波谱数据确定,其中化合物2、7首次在环草石斛中分离得到。

Dendrobium loddigesii is used in clinical applications widely. In order to further investigate its effective constituent, seven compounds including shihunine （1）, 9, 10-dihydrophenanthrene-2, 4, 7-triol （2）, moscatin （3）, loddigesiinols C （4）, moscatilin （5） , gigantol （6） and tristin （7） were i- solated by silica gel, Sephadex LH -20 and ODS -18 column chromatography from the methanol extract of Dendrobium loddigesii. Their structures were analyzed by MS and NMR spectroscopy. The compounds 2 and 7 were obtained from Dendrobium loddigesii for the first time.