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聚丙烯亚胺-聚谷氨酸苄酯多臂接枝聚合物的制备及其结构表征 被引量：1

Synthesis and Characterization of Multi-armed Polypropylenimine Dendrimer-poly(benzyl-L-glutamate) Graft Polymer
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摘要 以第二代聚丙烯亚胺树状大分子(PPI)末端的氨基为引发剂,与L-谷氨酸苄酯的N-酸酐(BLG-NCA)进行开环聚合合成了多臂聚丙烯亚胺-聚谷氨酸苄酯聚合物,分别用IR、1H NMR、13C NMR和GPC对聚合物结构进行表征。结果表明,PPI端氨基能够作为引发剂参与反应引发BLG-NCA开环聚合,并证实成功合成了多臂聚丙烯亚胺-聚谷氨酸苄酯聚合物。该聚合物有望成为新型的非病毒基因载体材料。 Multi-armed polypropylenimine dendrimer-poly （benzyl-L-glutamate） was synthesized by ring-opening polymerization of BLG-NCA using primary amine-terminated polypropylenimine dendrimer （PPI） as the macroinitiator. Its chemical structure was characterized by IR, I H NMR, 13C NMR, and GPC analysis. The results showed that the primary amine of PPI participated in initiating the ring-opening polymerization of BLG-NCA monomer. And multi-armed polypropylenimine dendrimer-poly （henzyl-L- glutamate） was successful synthesized. The muhi-armed polymer might be a potential candidate as nonviral gene carriers.
作者 张璇 鹏越峰 蔡青青
机构地区 深圳市精神卫生中心 深圳市心理健康重点实验室 中国科学院深圳先进技术研究院
出处 《中山大学学报（自然科学版）》 CAS CSCD 北大核心 2013年第3期83-86,92,共5页 Acta Scientiarum Naturalium Universitatis Sunyatseni
基金 国家自然科学基金资助项目(31100683)
关键词 聚丙烯亚胺树状大分子 聚谷氨酸苄酯 非病毒基因载体 开环聚合 polypropylenimine dendrimer poly （benzyl-L-glutamate） nonviral gene carrier ring-opening polymerization
分类号 O632 [理学—高分子化学]
  • 相关文献

参考文献12

  • 1PANDITA D, SANTOS J L, RODRIGUES J, et al. Gene delivery into mesenehymal stem cells: a biomimetie approach using RGD nanoclusters based on poly (amidoamine) dendrimers [ J ]. Biomacromolecules, 2011,12 ( 2 ) : 472 - 481.
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共引文献4

同被引文献14

  • 1SMITH D K. Dendrimers and the double Helix-From DNA binding towards gene therapy[J]. Curr Top Med Chem, 2008, 8(14):1187-1203.
  • 2KLINGLER J, KAUFMANN D. Polypropylenimine generation four: A suitable vector for targeted gene alteration in vitro [J]. J Drug Target, 2012, 20(5):474-480.
  • 3SMITH D K. Dendrimers and the double Helix-From DNA binding towards gene therapy [J]. Curr Top Med Chem, 2008, 8(14):1187-1203.
  • 4ZINSELMEYER B H, MACKAY S P, SCHATZLEIN A G, et al. The lower-generation polypropyleneimine dendrimers are effective gene-transfer agents [J]. Pharm Res, 2002, 19(7):960-967.
  • 5TACK F, BAKKER A, MAES S, et al. Dendrimeric poly(propylene-imines) as effective delivery agents for DNAzymes: Toxicity, in vitro transfection and in vivo delivery [J]. J Controlled Release, 2006, 116(2):26-28.
  • 6HAO J, SHA X, TANG Y, et al. Enhanced transfection of polyplexes based on pluronic-polypropylenimine dendrimer for gene transfer [J]. Arch Pharm Res, 2009, 32(7):1045-1054.
  • 7KOPPU S, OH Y J, EDRADA-EBEL R, et al. Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA[J]. J Controlled Release, 2010, 143(2):215-221.
  • 8TARATULA O, GARBUZENKO O B, KIRKPATRICK P, et al. Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery [J]. J Controlled Release, 2009, 140(3):284-293.
  • 9CHEN L, TIAN H, CHEN J, et al. Multi-armed poly(L-glutamic acid)-graft-oligoethylenimine copolymers as efficient nonviral gene delivery vectors [J]. J Gene Med, 2010, 12(1):64-76.
  • 10PAN S, CAO D, YI W, et al. A biodegradable and serum-resistant gene delivery carrier composed of polyamidoamine-poly N,N′-di-(2-aminoethyl) aminoethyl glutamine copolymer[J]. Colloids Surf B Biointerfaces, 2013, 104(1):294-302.

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中山大学学报（自然科学版）
2013年 第3期

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