摘要
以4-[2-(2,5-二甲基吡咯-1-基)乙氧基]乙酰乙酸乙酯、3-氨基丁烯酸甲酯和2-氯苯甲醛为起始原料,经Hantzsch成环、水解、成盐合成目标产物,总收率为53.7%。化合物经IR、1H-NMR、MS等确证。该方法具有原料易得、操作简便、收率较高、易于工业化生产等优点。
AmLodipine maleate was synthesized from ethyl 4- （2- （2, 5-dimethyl- 1H-pyrrol- 1-yl）ethoxy）-3-oxobutanoate, methyl 3-aminocrotonate and 2-chlorobenzaldehyde via Hantzsch reaction hydrolysis salification. The total yield was 53.7%. The structure of amlodipine was identified by IR, IH-NMR and MS. This method has several advantages of cheap reagents, facile reaction conditions, convenient operation and high yield.
出处
《安徽化工》
CAS
2013年第3期23-24,共2页
Anhui Chemical Industry
基金
合肥学院2012年大学生科技创新课题(11XSKY01)
