急性单侧低频感音神经性聋的治疗探讨

Treatment of acute unilateral low-frequency sensorineural hearing loss

目的探讨急性低频感音神经性聋的临床特点及治疗。方法回顾分析53例急性低频感音神经性聋患者临床资料,其中住院组38例(耳),门诊组15例(15耳),住院组口服强的松1 mg/kg×5 d,加用血管扩张剂和神经营养剂治疗;门诊组仅口服强的松片20 mg/d×5 d。1 w后复查听力,评估疗效。结果住院组的有效率89.5%(34/38),治愈率65.8%(25/38),门诊组有效率80.0%(12/15),治愈率53.3%(8/15),两组间的疗效比较差异无统计学意义(P>0.05)。结论急性低频感音神经性聋是一种有别于突发性耳聋的独立疾病,其发病机制可能与梅尼埃病关系密切,小剂量皮质类固醇激素门诊治疗有效。

Objective To discuss the clinical characteristics and treatment of acute low-frequency sensorineural hearing loss（ALHL）.Methods A retrospective analysis was made in the clinical data of 53 patients with ALHL.In hospitalization group,there were 38 cases（38 ears）,and in out-patient group,there were 15 cases（15 ears）.The hospitalization group orally took prednisone 1 mg / kg for 5 d and also received vasodilator and neurotrophic agents at the same time.The outpatient group only received prednisone 20 mg / kg.One week later,these patients were re-examined for hearing,and the curative effects were evaluated.Results In the hospitalization group,the effective rate was 89.5%（34 /38）,and the cure rate was 65.8%（25 /38）.In the out-patient group,the effective rate was 80.0%（12 /15）,and the cure rate was 53.3%（8 /15）.There was no significant difference of the curative effects between the two groups（P 0.05）.Conclusion Acute low-frequency sensorineural hearing loss is an independent disease which is different from sudden hearing loss.Its pathogenesis may have close correlation with meniere disease.Outpatient treatment with small dose of corticosteroid hormone is effective.